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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Psme4tm1Slek
targeted mutation 1, Barry P Sleckman
MGI:3623144
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Psme4tm1Slek/Psme4tm1Slek involves: 129 * C57BL/6 MGI:3625448


Genotype
MGI:3625448
hm1
Allelic
Composition		 Psme4tm1Slek/Psme4tm1Slek
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psme4tm1Slek mutation (0 available); any Psme4 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male germ cell morphology ( J:107376 )
• focal areas of abnormal spermatogenesis showing vacuolation, multinucleated giant germ cells, and hypospermatocytogenesis
asthenozoospermia ( J:107376 )
• many of spermatozoa present exhibited motility defects
abnormal spermatogenesis ( J:107376 )
• decrease in the level of mature spermatozoa
teratozoospermia ( J:107376 )
• many of spermatozoa present were malformed
abnormal spermatid morphology ( J:107376 )
• significant defects were noted in both meiotic spermatocytes and postmeiotic spermatids
abnormal spermatocyte morphology ( J:107376 )
• significant defects were noted in both meiotic spermatocytes and postmeiotic spermatids
reduced male fertility ( J:107376 )
• a marked reduction in male, but not female, fertility

cellular
abnormal male germ cell morphology ( J:107376 )
• focal areas of abnormal spermatogenesis showing vacuolation, multinucleated giant germ cells, and hypospermatocytogenesis
teratozoospermia ( J:107376 )
• many of spermatozoa present were malformed
abnormal spermatid morphology ( J:107376 )
• significant defects were noted in both meiotic spermatocytes and postmeiotic spermatids
abnormal spermatocyte morphology ( J:107376 )
• significant defects were noted in both meiotic spermatocytes and postmeiotic spermatids
asthenozoospermia ( J:107376 )
• many of spermatozoa present exhibited motility defects




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory