Phenotypes associated with this allele

• Allele Symbol: Isl1^tm1(cre)Sev
• Allele Name: targeted mutation 1, Sylvia Evans
• Allele ID: MGI:3623159
• Summary: 18 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bmp4^tm4Blh/Bmp4^tm4Blh Isl1^tm1(cre)Sev/Isl1^+	involves: 129 * 129S6/SvEvTac	MGI:5642272
cn2	Rspo3^tm1Arte/Rspo3^tm1Arte Isl1^tm1(cre)Sev/Isl1^+	involves: 129 * C57BL/6	MGI:5643693
cn3	Nkx2-5^tm1Krc/Nkx2-5^tm1Krc Isl1^tm1(cre)Sev/Isl1^+	involves: 129 * C57BL/6	MGI:5643691
cn4	Isl1^tm1(cre)Sev/Isl1^+ Pax9^tm1Rbal/Pax9^tm1.1Hpt	involves: 129 * C57BL/6J	MGI:7294563
cn5	Isl1^tm1(cre)Sev/Isl1^+ Msx1^tm1Rilm/Msx1^+ Pax9^tm1Rbal/Pax9^tm1.1Hpt	involves: 129 * CD-1	MGI:7294564
cn6	Jun^tm4Wag/Jun^tm4Wag Isl1^tm1(cre)Sev/Isl1^+	involves: 129P2/OlaHsd * 129S/Sv	MGI:7562242
cn7	Jun^tm1Pa/Jun^tm4Wag Isl1^tm1(cre)Sev/Isl1^+	involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ * C57BL/6J	MGI:7562004
cn8	Bcor^tm1.1Vjba/Bcor^+ Isl1^tm1(cre)Sev/Isl1^+	involves: 129S1/Sv	MGI:7343919
cn9	Bcor^tm1.1Vjba/Y Isl1^tm1(cre)Sev/Isl1^+	involves: 129S1/Sv	MGI:7343918
cn10	Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.2Bhr Isl1^tm1(cre)Sev/Isl1^+	involves: 129S4/SvJae * 129S7/SvEvBrd	MGI:3625139
cn11	Dvl3^tm1Awb/Dvl3^tm1Awb Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^+ Isl1^tm1(cre)Sev/Isl1^+	involves: 129S4/SvJaeSor * 129S6/SvEvTac * Black Swiss	MGI:3831923
cn12	Isl1^tm1(cre)Sev/Isl1^+ Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/0	involves: 129S7/SvEvBrd	MGI:5444492
cn13	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Isl1^tm1(cre)Sev/Isl1^+	involves: 129S/Sv	MGI:5444491
cn14	Fgf8^tm2Moon/Fgf8^tm1Mrc Isl1^tm1(cre)Sev/Isl1^+	involves: 129S/Sv	MGI:3639731
cn15	Smo^tm1Amc/Smo^tm2Amc Isl1^tm1(cre)Sev/Isl1^+	involves: 129S/Sv * 129X1/SvJ	MGI:3689403
cn16	Fgf8^tm1Mrc/Fgf8^tm2Moon Isl1^tm1(cre)Sev/Isl1^+	involves: 129S/Sv * Black Swiss * C57BL/6	MGI:3829040
cn17	Epha4^tm1.1Bzh/Epha4^tm1.1Bzh Isl1^tm1(cre)Sev/Isl1^+ Tg(Hlxb9-GFP)1Tmj/0	involves: 129S/Sv * Black Swiss * C57BL/6J * CD-1 * FVB/N	MGI:6406420
cn18	Isl1^tm1(cre)Sev/Isl1^+ Jun^tm4Wag/Jun^+	Not Specified	MGI:7562245

Genotype
MGI:5642272

cn1

• Allelic Composition: Bmp4^tm4Blh/Bmp4^tm4Blh; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129 * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hindlimb fusion of Bmp4^tm4Blh/Bmp4^tm4Blh Isl1^tm1(cre)Sev/Isl1⁺ mice

embryo

sirenomelia ( J:192045 )

• hindlimb fusion similar to sirenomelia

• 59% and 36% of mutants have defects consistent with type III (loss of the fibula) and type I (abnormal medial location of fibula), with the other 5% having type V sirenomelia (loss of the fibula and fusion of the femur)

abnormal embryonic cloaca development ( J:192045 )

• marker analysis indicates abnormal anterior peri-cloacal mesenchyme formation resulting in hypoplastic anterior peri-cloacal mesenchyme

abnormal hindlimb bud morphology ( J:192045 )

• the location of hindlimb bud is closely apposed to one another

• marker analysis suggests that posterior hindlimb buds are fused and that early hindlimb bud grows out normally but the midline tissue is missing

• however, the proximal-distal axis of the hindlimb bud is maintained

digestive/alimentary system

anal stenosis ( J:192045 )

limbs/digits/tail

abnormal fibula morphology ( J:192045 )

• defective fibula formation, with fibula aberrantly located medially or absent

abnormal limb development ( J:192045 )

• defective hindlimb initiation

sirenomelia ( J:192045 )

• hindlimb fusion similar to sirenomelia

• 59% and 36% of mutants have defects consistent with type III (loss of the fibula) and type I (abnormal medial location of fibula), with the other 5% having type V sirenomelia (loss of the fibula and fusion of the femur)

abnormal hindlimb bud morphology ( J:192045 )

• the location of hindlimb bud is closely apposed to one another

• marker analysis suggests that posterior hindlimb buds are fused and that early hindlimb bud grows out normally but the midline tissue is missing

• however, the proximal-distal axis of the hindlimb bud is maintained

renal/urinary system

abnormal renal/urinary system morphology ( J:192045 )

• dysgenesis of pelvic/urogenital organs

renal hypoplasia ( J:192045 )

absent urinary bladder ( J:192045 )

• bladder aplasia

reproductive system

abnormal external female genitalia morphology ( J:192045 )

• hypoplasia of external genitalia

external male genitalia hypoplasia ( J:192045 )

skeleton

abnormal fibula morphology ( J:192045 )

• defective fibula formation, with fibula aberrantly located medially or absent

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
physical disorder		DOID:0080015		J:192045

Genotype
MGI:5643693

cn2

• Allelic Composition: Rspo3^tm1Arte/Rspo3^tm1Arte; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:214093 )

• embryonic lethality at E11.5

cardiovascular system

blood vessel congestion ( J:214093 )

thin myocardium ( J:214093 )

• myocardial wall thickness is diminished at E10

abnormal cardiac outflow tract development ( J:214093 )

• poorly developed outflow tract

abnormal heart right ventricle morphology ( J:214093 )

• poorly developed right ventricle

pericardial edema ( J:214093 )

• in all mice

homeostasis/metabolism

pericardial edema ( J:214093 )

• in all mice

muscle

thin myocardium ( J:214093 )

• myocardial wall thickness is diminished at E10

Genotype
MGI:5643691

cn3

• Allelic Composition: Nkx2-5^tm1Krc/Nkx2-5^tm1Krc; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:214093 )

• early embryonic lethality at E10-E10.5

cardiovascular system

abnormal cardiac outflow tract development ( J:214093 )

• foreshortened outflow tract

• treatment of pregnant females from E8 to E10 with LiCl results in septation of the outflow tract in embryos, although it fails to correct the alignment defects of the outflow tract

absent heart right ventricle ( J:214093 )

• loss of right ventricle

• treatment of pregnant females from E8 to E10 with LiCl results in a larger right ventricle

Genotype
MGI:7294563

cn4

• Allelic Composition: Isl1^tm1(cre)Sev/Isl1⁺; Pax9^tm1Rbal/Pax9^tm1.1Hpt
• Genetic Background: involves: 129 * C57BL/6J

cardiovascular system

aberrant origin of the right subclavian artery ( J:311535 )

interrupted aortic arch ( J:311535 )

abnormal common carotid artery morphology ( J:311535 )

• absent common carotid arteries in 9 of 9 mice

double outlet right ventricle ( J:311535 )

• in 5 of 9 mice

ventricular septal defect ( J:311535 )

• in 1 of 9 mice

craniofacial

craniofacial phenotype ( J:311535 )

N • unlike in germline null mice, cleft palate is not seen

endocrine/exocrine glands

thymus hypoplasia ( J:311535 )

• hypoplastic and absent from the normal position

ectopic thymus ( J:311535 )

• hypoplastic and absent from the normal position

hematopoietic system

thymus hypoplasia ( J:311535 )

• hypoplastic and absent from the normal position

ectopic thymus ( J:311535 )

• hypoplastic and absent from the normal position

immune system

thymus hypoplasia ( J:311535 )

• hypoplastic and absent from the normal position

ectopic thymus ( J:311535 )

• hypoplastic and absent from the normal position

limbs/digits/tail

preaxial polydactyly ( J:311535 )

Genotype
MGI:7294564

cn5

• Allelic Composition: Isl1^tm1(cre)Sev/Isl1⁺; Msx1^tm1Rilm/Msx1⁺; Pax9^tm1Rbal/Pax9^tm1.1Hpt
• Genetic Background: involves: 129 * CD-1

mortality/aging

neonatal lethality, complete penetrance ( J:311535 )

skeleton

abnormal hyoid bone morphology ( J:311535 )

• ossification center is shorter

• angle between the greater and lesser horns is reduced

abnormal hyoid bone greater horn morphology ( J:311535 )

• reduced in length

abnormal hyoid bone lesser horn morphology ( J:311535 )

• extends laterally

abnormal inferior horn of thyroid cartilage morphology ( J:311535 )

• significantly shorter

abnormal superior horn of thyroid cartilage morphology ( J:311535 )

• reduced to a stump

craniofacial

craniofacial phenotype ( J:311535 )

• unlike in germline null mice, cleft palate is not seen

abnormal hyoid bone morphology ( J:311535 )

• ossification center is shorter

• angle between the greater and lesser horns is reduced

abnormal hyoid bone greater horn morphology ( J:311535 )

• reduced in length

abnormal hyoid bone lesser horn morphology ( J:311535 )

• extends laterally

limbs/digits/tail

preaxial polydactyly ( J:311535 )

cardiovascular system

aberrant origin of the right subclavian artery ( J:311535 )

• cervical origin in 2 of 8 neonates

respiratory system

abnormal inferior horn of thyroid cartilage morphology ( J:311535 )

• significantly shorter

abnormal superior horn of thyroid cartilage morphology ( J:311535 )

• reduced to a stump

Genotype
MGI:7562242

cn6

• Allelic Composition: Jun^tm4Wag/Jun^tm4Wag; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S/Sv

mortality/aging

mortality/aging ( J:199412 )

N • mice are present at the expected Mendelian ratios at E14.5-P0, indicating normal embryonic survival

cardiovascular system

abnormal pharyngeal arch artery morphology ( J:199412 )

• at E14.5 to P0, seven of 22 (32%) embryos exhibit aortic arch artery remodeling defects, including interrupted aortic arch (IAA) type B, hypoplasia of the B segment of the aortic arch, and aberrant retro-esophageal right subclavian artery

retroesophageal right subclavian artery ( J:199412 )

• at E14.5 to P0, seven of 22 (32%) embryos exhibit aberrant retro-esophageal right subclavian artery

interrupted aortic arch, type b ( J:199412 )

• at E14.5 to P0, seven of 22 (32%) embryos exhibit interrupted aortic arch (IAA) type B

abnormal cardiac outflow tract development ( J:199412 )

• at E14.5 to P0, seven of 8 (88%) embryos exhibit outflow tract (OFT) defects, including ventricular septal defect (VSD), double outlet right ventricle, and semilunar valve hyperplasia

• a non-significant trend toward a decrease in proliferating pHH3+ cells and an increase in apoptotic TUNEL+ cells is noted in the OFT at E10.5

double outlet right ventricle ( J:199412 )

• at E14.5 to P0, seven of 8 (88%) embryos exhibit DORV

ventricular septal defect ( J:199412 )

• at E14.5 to P0, seven of 8 (88%) embryos exhibit VSDs

abnormal aortic valve morphology ( J:199412 )

• at E14.5 to P0, six of 8 (75%) embryos exhibit an aortic valve defect

abnormal pulmonary valve morphology ( J:199412 )

• at E14.5 to P0, seven of 8 (88%) embryos exhibit a pulmonary valve defect

abnormal pulmonary valve cusp morphology ( J:199412 )

• at PO, pulmonary valve leaflets are enlarged and hyperplastic

semilunar valve hyperplasia ( J:199412 )

• at E14.5 to P0, seven of 8 (88%) embryos exhibit semilunar valve hyperplasia

• however, atrioventricular (mitral and tricuspid) valves are unaffected

embryo

abnormal pharyngeal arch artery morphology ( J:199412 )

• at E14.5 to P0, seven of 22 (32%) embryos exhibit aortic arch artery remodeling defects, including interrupted aortic arch (IAA) type B, hypoplasia of the B segment of the aortic arch, and aberrant retro-esophageal right subclavian artery

craniofacial

abnormal pharyngeal arch artery morphology ( J:199412 )

• at E14.5 to P0, seven of 22 (32%) embryos exhibit aortic arch artery remodeling defects, including interrupted aortic arch (IAA) type B, hypoplasia of the B segment of the aortic arch, and aberrant retro-esophageal right subclavian artery

Genotype
MGI:7562004

cn7

• Allelic Composition: Jun^tm1Pa/Jun^tm4Wag; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ * C57BL/6J

cardiovascular system

cardiovascular system phenotype ( J:199412 )

N • at E10.5, embryos show normal expression of Nfatc1 (an endocardial marker) relative to controls, suggesting normal endocardial formation

N • a non-significant trend toward a decrease in proliferating pHH3+ cells and an increase in apoptotic TUNEL+ cells is noted in the cardiac outflow tract (OFT) at E10.5

embryo

embryo phenotype ( J:199412 )

N • at E10.5, embryos show normal expression of Tfap2a during cardiac OFT development relative to controls, suggesting normal cardiac neural crest cell migration

Genotype
MGI:7343919

cn8

• Allelic Composition: Bcor^tm1.1Vjba/Bcor⁺; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129S1/Sv

cardiovascular system

persistent truncus arteriosus ( J:296645 )

♀ • at E13.5 in 7% of embryos

mortality/aging

preweaning lethality, incomplete penetrance ( J:296645 )

♀ • only 44% of expected mice survive to weaning

Genotype
MGI:7343918

cn9

• Allelic Composition: Bcor^tm1.1Vjba/Y; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129S1/Sv

cardiovascular system

abnormal aortic arch morphology ( J:296645 )

♂ • aortic arch abnormalities in 13% of hearts

persistent truncus arteriosus ( J:296645 )

♂ • at E13.5 in 65% of embryos

perimembraneous ventricular septal defect ( J:296645 )

♂ • at E13.5 and E14.5

limbs/digits/tail

syndactyly ( J:296645 )

♂ • show simple or complex syndactyly of the second and third digits in 4 of 17 embryos at E14.5

mortality/aging

lethality throughout fetal growth and development ( J:296645 )

♂ • begin to see decrease in numbers after E13.5

preweaning lethality, complete penetrance ( J:296645 )

♂ • none found at weaning

Genotype
MGI:3625139

cn10

• Allelic Composition: Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.2Bhr; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

embryo

abnormal hindlimb bud morphology ( J:107396 )

• by E11.5 ectopic outgrowths were observed on the ventral surface of the hindlimb bud

small hindlimb buds ( J:107396 )

• at E10, hindlimb buds were smaller

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:107396 )

• mutants were recovered at mendelian frequencies at E10.5

• began to be lost by E11.5 and no live mutant were recovered at E14.5

cardiovascular system

persistent truncus arteriosus ( J:107396 )

• abnormalities of outflow tract and right ventricle was evident by E8.5

• at E13.5 severe abnormalities of outflow tract formation with evident of persistent truncus arteriosus and underdeveloped valves

abnormal fetal cardiomyocyte proliferation ( J:107396 )

• proliferation of ventricular myocardium in the free wall and septum was also decreased in mutants relative to controls

muscle

abnormal fetal cardiomyocyte proliferation ( J:107396 )

• proliferation of ventricular myocardium in the free wall and septum was also decreased in mutants relative to controls

abnormal cardiomyocyte apoptosis ( J:107396 )

• decreased apoptosis in outflow tract cushions and increased apoptosis atop the ventricular septum

limbs/digits/tail

abnormal hindlimb bud morphology ( J:107396 )

• by E11.5 ectopic outgrowths were observed on the ventral surface of the hindlimb bud

small hindlimb buds ( J:107396 )

• at E10, hindlimb buds were smaller

abnormal hindlimb morphology ( J:107396 )

• by E13.5 hindlimb formation was severely abnormal

cellular

abnormal fetal cardiomyocyte proliferation ( J:107396 )

• proliferation of ventricular myocardium in the free wall and septum was also decreased in mutants relative to controls

abnormal cardiomyocyte apoptosis ( J:107396 )

• decreased apoptosis in outflow tract cushions and increased apoptosis atop the ventricular septum

decreased cell proliferation ( J:107396 )

• proliferation of developing hindlimb buds was severely decreased

Genotype
MGI:3831923

cn11

• Allelic Composition: Dvl3^tm1Awb/Dvl3^tm1Awb; Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * Black Swiss

cardiovascular system

cardiovascular system phenotype ( J:142392 )

N • at E10.5, E14.5 and E18.5, secondary heart field development is normal

Genotype
MGI:5444492

cn12

• Allelic Composition: Isl1^tm1(cre)Sev/Isl1⁺; Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/0
• Genetic Background: involves: 129S7/SvEvBrd

cardiovascular system

atrioventricular septal defect ( J:189007 )

• membranous defect

Genotype
MGI:5444491

cn13

• Allelic Composition: Irx3^tm3Hui/Irx3^tm3Hui; Irx5^tm3Hui/Irx5^tm3Hui; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129S/Sv

cardiovascular system

abnormal cardiac outflow tract development ( J:189007 )

• phenocopies abnormalities seen in germ line double null mice

persistent truncus arteriosus ( J:189007 )

double outlet right ventricle ( J:189007 )

abnormal interatrial septum morphology ( J:189007 )

• absence of the dorsal mesenchymal protrusion and the septum primum

atrial septal defect ( J:189007 )

• appears to be due to a defect in the fusion between the atrioventricular endocardial cushions and the dorsal mesenchymal protrusion

atrioventricular septal defect ( J:189007 )

• atrioventricular canal defect

Genotype
MGI:3639731

cn14

• Allelic Composition: Fgf8^tm2Moon/Fgf8^tm1Mrc; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129S/Sv

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:109475 )

• severely affected mutants (35%) die by E10; most (65%) survive to birth

embryo

small pharyngeal arch ( J:109475 )

• at E8.75 -10.5, surviving mutants have small pharyngeal arches

cellular

increased apoptosis ( J:109475 )

• excess apoptotic cells are detected at the 7-9 somite stage in ventral endoderm and adjacent smooth muscle

cardiovascular system

abnormal truncus arteriosus septation ( J:109475 )

• conotruncal cushions are hypocellular compared to controls; fusion of cushions to form AP septum is delayed in mutants

persistent truncus arteriosus ( J:109475 )

• 100% of E18.5/newborns have PTA

abnormal heart right ventricle morphology ( J:109475 )

• at E8.75 -10.5, surviving mutants have severe right ventricle hypoplasia

craniofacial

small pharyngeal arch ( J:109475 )

• at E8.75 -10.5, surviving mutants have small pharyngeal arches

Genotype
MGI:3689403

cn15

• Allelic Composition: Smo^tm1Amc/Smo^tm2Amc; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129S/Sv * 129X1/SvJ

mortality/aging

perinatal lethality ( J:110602 )

cardiovascular system

abnormal sixth pharyngeal arch artery morphology ( J:110602 )

• E10 embryos show an absence of the left 6th aortic arch although the right 6th arch is normal

abnormal aortic arch morphology ( J:110602 )

right aortic arch ( J:110602 )

abnormal cardiac outflow tract development ( J:110602 )

• outflow tracts are shortened by about 17%, 18% and 22% at E10.5, E11.5, and E12.5, respectively

• exhibit increased apoptosis in outflow tract myocardium at E10

persistent truncus arteriosus ( J:110602 )

• seen in 19 of 20 mutants at E18.5

transposition of great arteries ( J:110602 )

• seen in 1 of 20 mutants at E18.5

atrial septal defect ( J:110602 )

• E12.5 and E18.5 hearts show atrial septal defects

ventricular septal defect ( J:110602 )

• ventricular septal defects

embryo

abnormal sixth pharyngeal arch artery morphology ( J:110602 )

• E10 embryos show an absence of the left 6th aortic arch although the right 6th arch is normal

abnormal cardiac neural crest cell migration ( J:110602 )

• marker analysis indicates that cardiac neural crest cells are present in the pharyngeal arches and the outflow tract but do not penetrate the outflow tract to the same extent as in wild-type

craniofacial

abnormal sixth pharyngeal arch artery morphology ( J:110602 )

• E10 embryos show an absence of the left 6th aortic arch although the right 6th arch is normal

cellular

abnormal cardiac neural crest cell migration ( J:110602 )

• marker analysis indicates that cardiac neural crest cells are present in the pharyngeal arches and the outflow tract but do not penetrate the outflow tract to the same extent as in wild-type

Genotype
MGI:3829040

cn16

• Allelic Composition: Fgf8^tm1Mrc/Fgf8^tm2Moon; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:143444 )

• in explants no cells manage to successfully undergo endothelial to mesenchymal transformation

abnormal cardiac outflow tract development ( J:143444 )

• outflow tracts are short and abnormally angulated

abnormal conotruncal ridge morphology ( J:143444 )

• outflow tract cushions contain less cardiac jelly and fewer mesenchymal cells

• proximal outflow tract cushions are thinner and contain fewer cells while distal cushions are thinner but do not display a change in cell density

persistent truncus arteriosus ( J:143444 )

• all show type III PTA (the outflow tract is unseptated along its entire proximodstal extent)

Genotype
MGI:6406420

cn17

• Allelic Composition: Epha4^tm1.1Bzh/Epha4^tm1.1Bzh; Isl1^tm1(cre)Sev/Isl1⁺; Tg(Hlxb9-GFP)1Tmj/0
• Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6J * CD-1 * FVB/N

nervous system

abnormal innervation ( J:243785 )

• embryos show an increase in the number of abducens nerve bundles following exit from the hindbrain, reductions in both abducens nerve length and diameter at the orbit and larger wandering abducens nerve bundles that exhibit enhanced nerve pausing at the midpoint decision within the abducens fasciculation region

• however, trochlear nerve and first cervical spine projections are normal

abnormal abducens nerve morphology ( J:243785 )

• abducens nerve length is reduced and nerve diameter is thinner near the orbit in embryos

Genotype
MGI:7562245

cn18

• Allelic Composition: Isl1^tm1(cre)Sev/Isl1⁺; Jun^tm4Wag/Jun⁺
• Genetic Background: Not Specified

cardiovascular system

interrupted aortic arch, type b ( J:199412 )

• at E14.5 to P0, a single embryo (1 of 22) shows IAA type B

• however, no other OFT or aortic arch abnormalities are observed