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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cited1tm1Fmar
targeted mutation 1, Finian Martin
MGI:3623213
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cited1tm1Fmar/Cited1tm1Fmar involves: 129S4/SvJae MGI:3718979
cx2
 		Cited1tm1Fmar/Cited1tm1Fmar
Cited2tm1Bha/Cited2tm1Bha 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3718981
cx3
 		Cited1tm1Fmar/Cited1tm1Fmar
Cited2tm1Bha/Cited2+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3718982


Genotype
MGI:3718979
hm1
Allelic
Composition		 Cited1tm1Fmar/Cited1tm1Fmar
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Fmar mutation (1 available); any Cited1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:123322 )
N
• despite expression in the kidney during development, proximal tubule and glomerular formation are not significantly different to controls

endocrine/exocrine glands
abnormal mammary gland development ( J:107291 )
• retarded mammary ductal growth at puberty
abnormal branching of the mammary ductal tree ( J:107291 )
• dilated ductal structures with a lack of spatial restriction of the subtending branches

integument
abnormal mammary gland development ( J:107291 )
• retarded mammary ductal growth at puberty
abnormal branching of the mammary ductal tree ( J:107291 )
• dilated ductal structures with a lack of spatial restriction of the subtending branches




Genotype
MGI:3718981
cx2
Allelic
Composition		 Cited1tm1Fmar/Cited1tm1Fmar
Cited2tm1Bha/Cited2tm1Bha
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Fmar mutation (1 available); any Cited1 mutation (6 available)
Cited2tm1Bha mutation (3 available); any Cited2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:123322 )
• very few double homozygotes survive to E12

renal/urinary system
renal/urinary system phenotype ( J:123322 )
N
• E12 metanephric rudiments cultured for 5 days show fewer branch tips and new epithelial structures; however, too few embryos were recovered to demonstrate statistical significance of this difference




Genotype
MGI:3718982
cx3
Allelic
Composition		 Cited1tm1Fmar/Cited1tm1Fmar
Cited2tm1Bha/Cited2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Fmar mutation (1 available); any Cited1 mutation (6 available)
Cited2tm1Bha mutation (3 available); any Cited2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:123322 )
N
• despite expression in the kidney during development,, adult mice have normal kidney morphology




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory