Phenotypes associated with this allele

• Allele Symbol: Fkbp1b^tm1Amks
• Allele Name: targeted mutation 1, Andrew R Marks
• Allele ID: MGI:3623214
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fkbp1b^tm1Amks/Fkbp1b^tm1Amks	DBA/1LacJ-Fkbp1b^tm1Amks	MGI:3623679
hm2	Fkbp1b^tm1Amks/Fkbp1b^tm1Amks	involves: DBA/1LacJ	MGI:5582596

Genotype
MGI:3623679

hm1

• Allelic Composition: Fkbp1b^tm1Amks/Fkbp1b^tm1Amks
• Genetic Background: DBA/1LacJ-Fkbp1b^tm1Amks

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:107733 )

• following strenuous exercise and injection with epinephrine, mutant mice displayed polymorphic ventricular tachycardia followed by death

cardiovascular system

ventricular tachycardia ( J:107733 )

• consistently exhibited exercise-induced cardiac ventricular arrhythmias that cause sudden cardiac death

irregular heartbeat ( J:107733 )

• consistently exhibited exercise-induced cardiac ventricular arrhythmias that cause sudden cardiac death

• cardiac arrhythmias were observed in nonexercised animals

• no evidence of hypertension or cardiac hypertrophy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
catecholaminergic polymorphic ventricular tachycardia		DOID:0060674	OMIM:PS604772	J:107733

Genotype
MGI:5582596

hm2

• Allelic Composition: Fkbp1b^tm1Amks/Fkbp1b^tm1Amks
• Genetic Background: involves: DBA/1LacJ

cardiovascular system

atrial fibrillation ( J:212640 )

• induced by atrial burst pacing that is not prevented by 1,4-benzothiazepine (Rycal S107)-treatment