About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo
targeted mutation 2, Liqun Luo
MGI:3623346
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo involves: 129S1/Sv * 129X1/SvJ MGI:3665430
cn2
 		Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/Gt(ROSA)26Sortm1(Notch3*)Sfr
Notch3tm1.1(cre/ERT2)Sat/Notch3+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac MGI:5556107


Genotype
MGI:3665430
hm1
Allelic
Composition		 Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced female fertility ( J:113338 )
• homozygous females have low fertility




Genotype
MGI:5556107
cn2
Allelic
Composition		 Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/Gt(ROSA)26Sortm1(Notch3*)Sfr
Notch3tm1.1(cre/ERT2)Sat/Notch3+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Notch3*)Sfr mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Notch3tm1.1(cre/ERT2)Sat mutation (0 available); any Notch3 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased mammary gland epithelial cell proliferation ( J:201985 )
• following 4 weeks of tamoxifen treatment clonal expansion of cre expressing cells is markedly reduced

cellular
decreased mammary gland epithelial cell proliferation ( J:201985 )
• following 4 weeks of tamoxifen treatment clonal expansion of cre expressing cells is markedly reduced

integument
decreased mammary gland epithelial cell proliferation ( J:201985 )
• following 4 weeks of tamoxifen treatment clonal expansion of cre expressing cells is markedly reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory