Phenotypes associated with this allele

• Allele Symbol: Zfp148^tm1Djl
• Allele Name: targeted mutation 1, David J Law
• Allele ID: MGI:3623378
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp148^tm1Djl/Zfp148^tm1Djl	involves: 129	MGI:3624338

Genotype
MGI:3624338

hm1

• Allelic Composition: Zfp148^tm1Djl/Zfp148^tm1Djl
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:107441 )

• homozygous mice show an increased susceptibility to dextran sodium sulfate-induced colitis with 50% mortality by the end of 7 days

premature death ( J:107441 )

• homozygous mice show reduced viability with 50% mortality at 48 weeks and 69% mortality by 104 weeks

postnatal lethality, incomplete penetrance ( J:107441 )

• there is 20% mortality of homozygotes by time of weaning

growth/size/body

postnatal growth retardation ( J:107441 )

• homozygous mice show growth delay; at 3 weeks, male mutants weigh 12.1 grams compared to 15.1 grams for heterozygotes and 5.9 grams for wild-type

digestive/alimentary system

increased susceptibility to induced colitis ( J:107441 )

• after 5 days of DSS treatment, homozygous mice show areas of complete erosion of crypt architecture, grossly visible hemorrhage and extensive submucosal edema, while control mice have only localized areas of lymphocytic infiltration, and heterozygotes show displaced normal crypt architecture and edema with more extensive infiltration than controls

immune system

increased susceptibility to induced colitis ( J:107441 )

• after 5 days of DSS treatment, homozygous mice show areas of complete erosion of crypt architecture, grossly visible hemorrhage and extensive submucosal edema, while control mice have only localized areas of lymphocytic infiltration, and heterozygotes show displaced normal crypt architecture and edema with more extensive infiltration than controls

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:107441 )

• homozygous mice show an increased susceptibility to dextran sodium sulfate-induced colitis with 50% mortality by the end of 7 days