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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pomc1-cre)1Mlf
transgene insertion 1, Matthew L Fero
MGI:3623445
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cdkn1btm2Mlf/Cdkn1btm2Mlf
Tg(Pomc1-cre)1Mlf/0
involves: 129S4/SvJaeSor MGI:3624681
cn2
Cdkn1btm3Mlf/Cdkn1btm3Mlf
Tg(Pomc1-cre)1Mlf/0
involves: 129S4/SvJaeSor MGI:3624683


Genotype
MGI:3624681
cn1
Allelic
Composition
Cdkn1btm2Mlf/Cdkn1btm2Mlf
Tg(Pomc1-cre)1Mlf/0
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1btm2Mlf mutation (1 available); any Cdkn1b mutation (26 available)
Tg(Pomc1-cre)1Mlf mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice have shortened life spans compared to wild-type but increased survival times compared to Cdkn1b-deficient (nontransgenic) animals

neoplasm
• transgenic mice develop pituitary tumors at an increased incidence over wild-type or nontransgenic mutant mice

endocrine/exocrine glands
• transgenic mice develop pituitary tumors at an increased incidence over wild-type or nontransgenic mutant mice

nervous system
• transgenic mice develop pituitary tumors at an increased incidence over wild-type or nontransgenic mutant mice




Genotype
MGI:3624683
cn2
Allelic
Composition
Cdkn1btm3Mlf/Cdkn1btm3Mlf
Tg(Pomc1-cre)1Mlf/0
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1btm3Mlf mutation (1 available); any Cdkn1b mutation (26 available)
Tg(Pomc1-cre)1Mlf mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice have shortened life spans compared to wild-type but increased survival times compared to Cdkn1b-deficient (nontransgenic) animals

neoplasm
• transgenic mice are mostly resistant to tumor formation, but some develop smaller pituitary tumors at 1 year of age; before 1 year of age, 32% of mutants die from nonmalignant skin ulcers, but only two of these were found to have large pituitary tumors





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory