mortality/aging
• mice have shortened life spans compared to wild-type but increased survival times compared to Cdkn1b-deficient (nontransgenic) animals
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neoplasm
• transgenic mice develop pituitary tumors at an increased incidence over wild-type or nontransgenic mutant mice
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endocrine/exocrine glands
• transgenic mice develop pituitary tumors at an increased incidence over wild-type or nontransgenic mutant mice
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nervous system
• transgenic mice develop pituitary tumors at an increased incidence over wild-type or nontransgenic mutant mice
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