Phenotypes associated with this allele

• Allele Symbol: Ptgdr2^tm1Byl
• Allele Name: targeted mutation 1, Baiyong Li
• Allele ID: MGI:3623476
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgdr2^tm1Byl/Ptgdr2^tm1Byl	involves: C57BL/6J	MGI:3624532

Genotype
MGI:3624532

hm1

• Allelic Composition: Ptgdr2^tm1Byl/Ptgdr2^tm1Byl
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased eosinophil cell number ( J:107519 )

• in an OVA-elicited airway inflammation model, mutants show a dramatically increased eosinophil count in BAL fluid and in lungs compared to wild-type littermates

abnormal cytokine secretion ( J:107519 )

• splenocytes from mutant mice show enhanced production of Il5 upon stimulation in vitro; anti-CD3 stimulation results in a 5-fold increase in Il5 production vs. wild-type or a 2.5-fold increase in combination with anti-CD28 stimulation

hematopoietic system

increased eosinophil cell number ( J:107519 )

• in an OVA-elicited airway inflammation model, mutants show a dramatically increased eosinophil count in BAL fluid and in lungs compared to wild-type littermates