All Phenotypes Reck<tm1Ito> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Reck^tm1Ito/Reck^tm1Ito	either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J)	MGI:3687636
hm2	Reck^tm1Ito/Reck^tm1Ito	involves: 129P2/OlaHsd	MGI:4830344
cn3	Reck^tm1Ito/Reck^tm1.1Noda Tg(CAG-cre/Esr1*)5Amc/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4830343
cx4	Mmp2^tm1Ito/Mmp2^tm1Ito Reck^tm1Ito/Reck^tm1Ito	involves: 129P2/OlaHsd * C57BL/6	MGI:3687637

Allelic Composition	Reck^tm1Ito/Reck^tm1Ito
Genetic Background	either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Reck^tm1Ito mutation (1 available); any Reck mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:107674 )

• 2/3 die around E10.5 and none survive beyond E11.5

growth/size/body

decreased embryo size ( J:107674 )

embryo

decreased embryo size ( J:107674 )

abnormal vitelline vascular remodeling ( J:107674 )

• although vascular networks form in the yolk sac, their morphology resembles primitive vascular plexuses, suggesting defects in blood vessel maturation

cardiovascular system

abnormal vascular endothelial cell morphology ( J:107674 )

• vascular endothelial cells do not form tight and thin tubular structures

abnormal angiogenesis ( J:107674 )

• although vascular networks form in the embryo, their morphology resembles primitive vascular plexuses, suggesting defects in blood vessel maturation

internal hemorrhage ( J:107674 )

• frequently exhibit abdominal hemorrhage

cellular

abnormal basal lamina morphology ( J:107674 )

• exhibit almost complete loss of collagen fibrils and a discontinuous basal lamina surrounding the neural tube and blood vessels

Allelic Composition	Reck^tm1Ito/Reck^tm1Ito
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Reck^tm1Ito mutation (1 available); any Reck mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:163845 )

• at E10.5, the series of periodically spaced contact zones in the pernineural vascular basement membrane compared to in wild-type mice

dilated vasculature ( J:163845 )

• at E10.5

hemorrhage ( J:163845 )

• at E10.5, mice exhibit abdominal hemorrhage unlike wild-type mice

embryo

abnormal vitelline vascular remodeling ( J:163845 )

• yolk sacs exhibit irregularly shaped sprouts or branches instead of the numerous small holes in the arterial domain observed in wild-type mice

• in the lateral regions, arteries are winding and variable in thickness compared to in wild-type yolk sac

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:163845 )

• mice treated with tamoxifen at E11 die after E15.5

cardiovascular system

abnormal blood vessel morphology ( J:163845 )

• at E15.5, blood vessels in tamoxifen-treated mice are large and irregularly shaped compared to in wild-type mice

abnormal brain vasculature morphology ( J:163845 )

• brain vasculature in tamoxifen-treated mice is disorganized and interrupted by large spaces and cavities unlike in wild-type mice

abnormal liver vasculature morphology ( J:163845 )

• the blood vessels in the livers of tamoxifen-treated mice exhibit larger luminal spaces than in wild-type mice

abnormal developmental vascular remodeling ( J:163845 )

• at E15.5, blood vessels in tamoxifen-treated mice are large and irregularly shaped compared to in wild-type mice

• brain vasculature in tamoxifen-treated mice is disorganized and interrupted by large spaces and cavities unlike in wild-type mice

• the blood vessels in the livers of tamoxifen-treated mice exhibit larger luminal spaces than in wild-type mice

dilated vasculature ( J:163845 )

• in tamoxifen-treated mice

hemorrhage ( J:163845 )

• at E15.5 in tamoxifen-treated mice

growth/size/body

decreased fetal size ( J:163845 )

• at E15.5 in tamoxifen-treated mice

liver/biliary system

abnormal liver vasculature morphology ( J:163845 )

• the blood vessels in the livers of tamoxifen-treated mice exhibit larger luminal spaces than in wild-type mice

nervous system

abnormal brain vasculature morphology ( J:163845 )

• brain vasculature in tamoxifen-treated mice is disorganized and interrupted by large spaces and cavities unlike in wild-type mice

integument

pallor ( J:163845 )

• at E15.5 in tamoxifen-treated mice

Allelic Composition	Mmp2^tm1Ito/Mmp2^tm1Ito Reck^tm1Ito/Reck^tm1Ito
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp2^tm1Ito mutation (1 available); any Mmp2 mutation (25 available)
Reck^tm1Ito mutation (1 available); any Reck mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:107674 )

• 2/3 die by E11 and none survive beyond E11.5, however exhibit partial rescue of the phenotypes seen in single Reck homozygotes such as increased body size and tissue integrity

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