Phenotypes associated with this allele

• Allele Symbol: Grik2^tm1Bvis
• Allele Name: targeted mutation 1, B Vissel
• Allele ID: MGI:3623590
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grik2^tm1Bvis/Grik2^tm1Bvis	129S/Sv-Grik2^tm1Bvis	MGI:3624528

Genotype
MGI:3624528

hm1

• Allelic Composition: Grik2^tm1Bvis/Grik2^tm1Bvis
• Genetic Background: 129S/Sv-Grik2^tm1Bvis

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to pharmacologically induced seizures ( J:107698 )

• increased susceptibility to kainite induced seizures

abnormal single cell response ( J:107698 )

• rectifying kainite receptor responses seen in hippocampal neurons when AMPA and NMDA receptors are blocked as opposed to the linear current/voltage characteristics of controls

• increased cell levels of calcium

abnormal CNS synaptic transmission ( J:107698 )

abnormal excitatory postsynaptic potential ( J:107698 )

• 27% alteration in the EPSP slope following high frequency stimulation

abnormal long-term potentiation ( J:107698 )

• NMDA receptor independent LTP observed

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:107698 )

• increased susceptibility to kainite induced seizures