Phenotypes associated with this allele

• Allele Symbol: Ackr2^tm1Gjg
• Allele Name: targeted mutation 1, Gerard J Graham
• Allele ID: MGI:3623613
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ackr2^tm1Gjg/Ackr2^tm1Gjg	involves: 129/Sv * C57BL/6	MGI:3623929

Genotype
MGI:3623929

hm1

• Allelic Composition: Ackr2^tm1Gjg/Ackr2^tm1Gjg
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:97806 )

N • normal lifespan

immune system

increased inflammatory response ( J:97806 )

• subcutaneous injection of complete Freund's adjuvant (CFA) produces a granuloma-like lesion in homozygotes by 3 days post injection and 18 of 28 mutants develop grade 2 or higher lesions by 7 days post injection versus 2 of 28 wild-type mice

• at the site of CFA injection increased necrosis, angiogenesis and leukocyte infiltration are seen

• 3 days after CFA injection increase lymph node cellularity is seen in homozygotes compared to wild-type mice; however 7 days after injection wild-type contralateral lymph nodes display hyperplasia which is not seen in homozygotes

dermatitis ( J:97607 )

• 24 hours after a single exposure of dorsal skin to 12-O-tetradecanoylphorbol-13-acetate (TPA) beta-chemokine levels remain elevated suggesting a defect in post-inflammatory clearance

• after 3 daily applications of TPA homozygotes develop a psoriasis-like skin lesion that is characterized by skin thickening, basal and suprabasal epidermal hyperproliferation, severe epidermal acanthosis, parakeratosis, hyperkeratosis, extensive growth of convoluted blood vessels, and a dense inflammatory cell infiltrate that includes high numbers of T cells

• this TPA-induced inflammatory skin lesion persists for 6 to 10 days

• injection of TNF neutralizing antibodies, depletion of CD4+ and CD8+ T cells, or blockage of mast cell degranulation can prevent development of the TPA-induced psoriaform lesion

reproductive system

reproductive system phenotype ( J:97806 )

N • both sexes are fertile

integument

dermatitis ( J:97607 )

• 24 hours after a single exposure of dorsal skin to 12-O-tetradecanoylphorbol-13-acetate (TPA) beta-chemokine levels remain elevated suggesting a defect in post-inflammatory clearance

• after 3 daily applications of TPA homozygotes develop a psoriasis-like skin lesion that is characterized by skin thickening, basal and suprabasal epidermal hyperproliferation, severe epidermal acanthosis, parakeratosis, hyperkeratosis, extensive growth of convoluted blood vessels, and a dense inflammatory cell infiltrate that includes high numbers of T cells

• this TPA-induced inflammatory skin lesion persists for 6 to 10 days

• injection of TNF neutralizing antibodies, depletion of CD4+ and CD8+ T cells, or blockage of mast cell degranulation can prevent development of the TPA-induced psoriaform lesion