Phenotypes associated with this allele

• Allele Symbol: Mapk7^tm1Jsca
• Allele Name: targeted mutation 1, J Simon C Arthur
• Allele ID: MGI:3623627
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapk7^tm1Jsca/Mapk7^tm1Jsca	either: (involves: BALB/c) or (involves: C57BL/6)	MGI:3623799

Genotype
MGI:3623799

hm1

• Allelic Composition: Mapk7^tm1Jsca/Mapk7^tm1Jsca
• Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Morphology of wild type and Mapk7^tm1Jsca/Mapk7^tm1Jsca yolk sacs

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:107620 )

• die between E10.5 and E11.5

growth/size/body

embryonic growth retardation ( J:107620 )

• visible at E10.25 with some embryos (class I) showing severe growth retardation especially in the head and lower trunk regions and others (class II) with milder growth retardation and abnormal head and lower trunk development

• in the lower trunk growth retardation is seen around the septum transversum

abnormal head morphology ( J:107620 )

• seen in class II embryos by E10.25

abnormal head mesenchyme morphology ( J:107620 )

• at E9.75, development of the lumen in the head region is retarded, the cephalic mesenchyme is less dense, and contact between the cephalic mesenchyme and neuroepithelium is decreased

• by E10.25, class II embryos show more severe defects in the cephalic mesenchyme as well as extensive loss of cephalic mesenchyme

embryo

small first pharyngeal arch ( J:107620 )

• by E10.25, class II embryos display reduced development of the first branchial arches

small second pharyngeal arch ( J:107620 )

• by E10.25, class II embryos display reduced development of the second branchial arches

embryonic growth retardation ( J:107620 )

• visible at E10.25 with some embryos (class I) showing severe growth retardation especially in the head and lower trunk regions and others (class II) with milder growth retardation and abnormal head and lower trunk development

• in the lower trunk growth retardation is seen around the septum transversum

abnormal head mesenchyme morphology ( J:107620 )

• at E9.75, development of the lumen in the head region is retarded, the cephalic mesenchyme is less dense, and contact between the cephalic mesenchyme and neuroepithelium is decreased

• by E10.25, class II embryos show more severe defects in the cephalic mesenchyme as well as extensive loss of cephalic mesenchyme

abnormal septum transversum morphology ( J:107620 )

• in the lower trunk growth retardation is seen around the septum transversum

abnormal placenta labyrinth morphology ( J:107620 )

• thinner with increased apoptosis at E10.25

abnormal placental labyrinth vasculature morphology ( J:107620 )

• decreased intermixing of embryonic and maternal blood vessels at E10.25

abnormal vitelline vascular remodeling ( J:107620 )

• by E10.25, all embryos fail to develop highly branched vasculature

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:107620 )

• decreased intermixing of embryonic and maternal blood vessels at E10.25

abnormal angiogenesis ( J:107620 )

• at E10.25, vascular branching is decreased in the head

thin myocardium ( J:107620 )

• at E9.25

hemorrhage ( J:107620 )

• bleeding is seen in some mice with thin myocardial walls

intracerebral hemorrhage ( J:107620 )

• vessels within the cephalic mesenchyme frequently rupture with bleeding mostly occurring in areas where the surrounding mesenchyme is absent

nervous system

intracerebral hemorrhage ( J:107620 )

• vessels within the cephalic mesenchyme frequently rupture with bleeding mostly occurring in areas where the surrounding mesenchyme is absent

abnormal brain development ( J:107620 )

• the neuroepithelial layer surrounding the area where the cephalic mesenchyme is normally located is thinner

• increase apoptosis is seen at E9.75

digestive/alimentary system

abnormal digestive system development ( J:107620 )

• abnormal development of the mid and hind gut with overproliferation of cells seen in some areas of the gut wall at E9.75; however development of the foregut appears normal

craniofacial

small first pharyngeal arch ( J:107620 )

• by E10.25, class II embryos display reduced development of the first branchial arches

small second pharyngeal arch ( J:107620 )

• by E10.25, class II embryos display reduced development of the second branchial arches

muscle

thin myocardium ( J:107620 )

• at E9.25