Phenotypes associated with this allele

• Allele Symbol: Gata6^tm2Msp
• Allele Name: targeted mutation 2, Michael S Parmacek
• Allele ID: MGI:3623678
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gata6^tm2Msp/Gata6^tm2Msp H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3623951
cn2	Gata6^tm2Msp/Gata6^tm2Msp Tg(Tagln-cre)1Jjl/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3623950

Genotype
MGI:3623951

cn1

• Allelic Composition: Gata6^tm2Msp/Gata6^tm2Msp; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:107814 )

• die between E18.5 and P1

cardiovascular system

abnormal cardiovascular system morphology ( J:107814 )

• exhibit a spectrum of aortic arch patterning and cardiac outflow tract septation defects indistinguishable from those seen in mice homozygous for Gata6^tm2Msp and hemizygous for Tg(Tagln-cre)1Jjl

retroesophageal right subclavian artery ( J:107814 )

aortic arch hypoplasia ( J:107814 )

• hypoplastic aortic arch

interrupted aortic arch ( J:107814 )

persistent truncus arteriosus ( J:107814 )

• seen as early as E9.5

double outlet right ventricle ( J:107814 )

perimembraneous ventricular septal defect ( J:107814 )

• membranous ventricular septal defect

Genotype
MGI:3623950

cn2

• Allelic Composition: Gata6^tm2Msp/Gata6^tm2Msp; Tg(Tagln-cre)1Jjl/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

mortality/aging

perinatal lethality, complete penetrance ( J:107814 )

• all die between E18.5 and P2

cardiovascular system

retroesophageal right subclavian artery ( J:107814 )

• 6 of 11 embryos show a retroesophageal right subclavian artery

aortic arch hypoplasia ( J:107814 )

• 7 of 11 embryos exhibit a hypoplastic aortic arch

interrupted aortic arch ( J:107814 )

• 7 of 11 embryos have an interrupted aortic arch

absent fetal ductus arteriosus ( J:107814 )

• seen in 1/11 mutant mice

persistent truncus arteriosus ( J:107814 )

• seen in 7 of 11 embryos

double outlet right ventricle ( J:107814 )

• seen in 4 of 11 embryos

perimembraneous ventricular septal defect ( J:107814 )

• all embryos exhibit a membranous ventricular septal defect

homeostasis/metabolism

cyanosis ( J:107814 )

• several newborns are cyanotic and expire shortly after birth