Phenotypes associated with this allele

• Allele Symbol: Kif2a^tm1Noh
• Allele Name: targeted mutation 1, Nobutaka Hirokawa
• Allele ID: MGI:3623680
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif2a^tm1Noh/Kif2a^tm1Noh	involves: 129S4/SvJae * C57BL/6J	MGI:3623761

Genotype
MGI:3623761

hm1

• Allelic Composition: Kif2a^tm1Noh/Kif2a^tm1Noh
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:107737 )

• all die within 1 day of birth

nervous system

delayed neuronal migration ( J:107737 )

• cortical granular neurons born at E14 have not reach their destinations by P0 suggesting a migratory defect

• facial nerve neurons are scattered during migration and show a migratory delay

enlarged brain ventricles ( J:107737 )

• enlarged ventricles

abnormal midbrain morphology ( J:107737 )

abnormal tegmentum morphology ( J:107737 )

• lack of nuclei in the trochlear nucleus

abnormal trigeminal V mesencephalic nucleus morphology ( J:107737 )

• lack of nuclei

abnormal forebrain morphology ( J:107737 )

abnormal hippocampus layer morphology ( J:107737 )

abnormal stratification in cerebral cortex ( J:107737 )

• abnormal laminar structure

abnormal hindbrain morphology ( J:107737 )

abnormal inferior olivary complex morphology ( J:107737 )

• lack of nuclei

abnormal pons morphology ( J:107737 )

• lack of nuclei in the basilar pontine nucleus and facial nerve nucleus

abnormal pontine nuclei morphology ( J:107737 )

• lack of nuclei in the basilar pontine nucleus

abnormal cerebellum morphology ( J:107737 )

• abnormal laminar structure

abnormal nervous system development ( J:107737 )

abnormal axon extension ( J:107737 )

• neurons in the cerebral cortex and hippocampal CA1 region extend about 4-fold more collateral branches from the primary axon and these branches are longer

• low density cultures of hippocampal neurons display longer collateral branches which form longer tertiary and quaternary branches and active shrinkage of these collaterals is reduced compared to wild-type neurons

• microtubule depolymerization is reduced in the growth cones of cultured mutant hippocampal neurons

abnormal axon morphology ( J:107737 )

• the facial nerve axon bundle is extensively defasciculated during migration unlike in wild-type mice

• many horizontally running neurites, identified as axonal collateral branches, are seen in the brain

behavior/neurological

abnormal suckling behavior ( J:107737 )

• fail to suckle

cellular

abnormal axon extension ( J:107737 )

• neurons in the cerebral cortex and hippocampal CA1 region extend about 4-fold more collateral branches from the primary axon and these branches are longer

• low density cultures of hippocampal neurons display longer collateral branches which form longer tertiary and quaternary branches and active shrinkage of these collaterals is reduced compared to wild-type neurons

• microtubule depolymerization is reduced in the growth cones of cultured mutant hippocampal neurons

delayed neuronal migration ( J:107737 )

• cortical granular neurons born at E14 have not reach their destinations by P0 suggesting a migratory defect

• facial nerve neurons are scattered during migration and show a migratory delay