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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tex14tm1Zuk
targeted mutation 1, Martin M Matzuk
MGI:3623684
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tex14tm1Zuk/Tex14tm1Zuk 129S/SvEv-Tex14tm1Zuk MGI:3624016
hm2
 		Tex14tm1Zuk/Tex14tm1Zuk either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J) MGI:3624029


Genotype
MGI:3624016
hm1
Allelic
Composition		 Tex14tm1Zuk/Tex14tm1Zuk
Genetic
Background		 129S/SvEv-Tex14tm1Zuk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tex14tm1Zuk mutation (0 available); any Tex14 mutation (159 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Spermatogenesis is disrupted in Tex14tm1Zuk/Tex14tm1Zuk male mice

reproductive system
abnormal spermatocyte morphology ( J:107660 )
• testes of postnatal day 10 males contained fewer spermatocytes than heterozygous mice
• mutant males 21 days of age display severe degeneration and depletion of spermatocytes
arrest of male meiosis ( J:107660 )
• early meiotic markers are expressed but meiosis is disrupted before completion of the first meiotic division
• germ cell intercellular bridges are not formed
• meiosis is disrupted during the first cycle of spermatogenesis
abnormal Sertoli cell morphology ( J:107660 )
• testes of postnatal day 10 males show early signs of Sertoli cell vacuolization due to germ cell depletion
small testis ( J:107660 )
• testes from both juvenile and adult males are significantly smaller than testes of normal males
decreased testis weight ( J:107660 )
• testes weight of 6 week old mutant males are 26% the weight of wild-type males

endocrine/exocrine glands
abnormal Sertoli cell morphology ( J:107660 )
• testes of postnatal day 10 males show early signs of Sertoli cell vacuolization due to germ cell depletion
small testis ( J:107660 )
• testes from both juvenile and adult males are significantly smaller than testes of normal males
decreased testis weight ( J:107660 )
• testes weight of 6 week old mutant males are 26% the weight of wild-type males

cellular
abnormal spermatocyte morphology ( J:107660 )
• testes of postnatal day 10 males contained fewer spermatocytes than heterozygous mice
• mutant males 21 days of age display severe degeneration and depletion of spermatocytes
arrest of male meiosis ( J:107660 )
• early meiotic markers are expressed but meiosis is disrupted before completion of the first meiotic division
• germ cell intercellular bridges are not formed
• meiosis is disrupted during the first cycle of spermatogenesis




Genotype
MGI:3624029
hm2
Allelic
Composition		 Tex14tm1Zuk/Tex14tm1Zuk
Genetic
Background		 either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tex14tm1Zuk mutation (0 available); any Tex14 mutation (159 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
arrest of male meiosis ( J:107660 )
• meiosis is disrupted before completion of the first meiotic division
• germ cell intercellular bridges do not form in mutant mice

endocrine/exocrine glands

cellular
arrest of male meiosis ( J:107660 )
• meiosis is disrupted before completion of the first meiotic division
• germ cell intercellular bridges do not form in mutant mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory