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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hpgdstm1Urad
targeted mutation 1, Yoshihiro Urade
MGI:3623744
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hpgdstm1Urad/Hpgdstm1Urad B6.129-Hpgdstm1Urad MGI:3624260
cx2
 		Galctwi/Galctwi
Hpgdstm1Urad/Hpgdstm1Urad 		B6.Cg-Hpgdstm1Urad Galctwi MGI:3624279
cx3
 		ApcMin/Apc+
Hpgdstm1Urad/Hpgds+ 		involves: 129 * C57BL/6J MGI:3700063
cx4
 		ApcMin/Apc+
Hpgdstm1Urad/Hpgdstm1Urad 		involves: 129 * C57BL/6J MGI:3700064


Genotype
MGI:3624260
hm1
Allelic
Composition		 Hpgdstm1Urad/Hpgdstm1Urad
Genetic
Background		 B6.129-Hpgdstm1Urad
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hpgdstm1Urad mutation (0 available); any Hpgds mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymph node morphology ( J:107651 )
• in response to BSA or concanavalin A, lymph node cellular proliferation is significantly greater in cultures from mutant mice at all time points compared to wild-type controls
abnormal cytokine secretion ( J:107651 )
• in response to BSA or concanavalin A, Il-2 levels in lymph node cultures from mutants are much higher than in cultures from control mice at 24 hours
increased inflammatory response ( J:107651 )
• upon injection of BSA into sensitized mutants, swelling of the paw is apparent after 1 hour, significantly greater at all time points and fails to resolve by 96 hours compared to controls
increased acute inflammation ( J:107651 )
• paws of mutants show increased neutrophil infiltrate than in wild-type mice in response to an inflammatory challenge; neutrophils accumulate subcutaneously in foci of keratin crust and form small subcorneal microabcesses not detected in wild-type
increased susceptibility to type I hypersensitivity reaction ( J:197334 )
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit increased dye extravasation (a measure of edema) compared with wild-type mice

integument
mixed cellular infiltration to dermis ( J:107651 )
• in the dermis and skeletal muscle of some mutants, there are dense accumulations of neutrophils forming small microabcesses not detected in wild-type

homeostasis/metabolism
edema ( J:197334 )
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit increased dye extravasation (a measure of edema) compared with wild-type mice




Genotype
MGI:3624279
cx2
Allelic
Composition		 Galctwi/Galctwi
Hpgdstm1Urad/Hpgdstm1Urad
Genetic
Background		 B6.Cg-Hpgdstm1Urad Galctwi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galctwi mutation (1 available); any Galc mutation (46 available)
Hpgdstm1Urad mutation (0 available); any Hpgds mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:108359 )
• lifespan of mutants is 47.3 days

cellular
decreased apoptosis ( J:108359 )
• fewer apoptotic oligodendrocytes are detected in double mutants compared to Galctwi single mutants

behavior/neurological
ataxia ( J:108359 )
• milder than in Galctwi single mutants

nervous system
abnormal astrocyte morphology ( J:108359 )
• astrocyte processes are much thinner than in Galctwi single mutants




Genotype
MGI:3700063
cx3
Allelic
Composition		 ApcMin/Apc+
Hpgdstm1Urad/Hpgds+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Hpgdstm1Urad mutation (0 available); any Hpgds mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenoma incidence ( J:118232 )
• mice have 44-61% more intestinal adenomas than Apc-heterozygous controls
• 95% of adenomas are in small intestine, while colon adenomas are increased 2-fold
• adenomas tend to be smaller than in wild-type APC mutants (~.5 mm vs 0.68 mm in controls but difference is not significant

digestive/alimentary system
increased intestinal adenoma incidence ( J:118232 )
• mice have 44-61% more intestinal adenomas than Apc-heterozygous controls
• 95% of adenomas are in small intestine, while colon adenomas are increased 2-fold
• adenomas tend to be smaller than in wild-type APC mutants (~.5 mm vs 0.68 mm in controls but difference is not significant




Genotype
MGI:3700064
cx4
Allelic
Composition		 ApcMin/Apc+
Hpgdstm1Urad/Hpgdstm1Urad
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Hpgdstm1Urad mutation (0 available); any Hpgds mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenoma incidence ( J:118232 )
• mice have 44-61% more intestinal adenomas than Apc-heterozygous controls
• 95% of adenomas are in small intestine, while colon adenomas are increased 2-fold
• adenomas tend to be smaller than in wild-type APC mutants (~.5 mm vs 0.68 mm in controls but difference is not significant

digestive/alimentary system
increased intestinal adenoma incidence ( J:118232 )
• mice have 44-61% more intestinal adenomas than Apc-heterozygous controls
• 95% of adenomas are in small intestine, while colon adenomas are increased 2-fold
• adenomas tend to be smaller than in wild-type APC mutants (~.5 mm vs 0.68 mm in controls but difference is not significant




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory