All Phenotypes Nck2<tm3Paw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nck2^tm3Paw
targeted mutation 3, Tony Pawson
MGI:3623745

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Apoe^tm1Unc/Apoe^tm1Unc Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw Tg(Cdh5-cre/ERT2)1Rha/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7316557
cn2	Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw Tg(Nphs2-cre)1Seq/0	involves: 129S1/Sv * 129X1/SvJ	MGI:3624130
cn3	Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm1Paw/Nck2^tm3Paw Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:3769794

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Nck1^tm1Paw mutation (2 available); any Nck1 mutation (40 available)
Nck2^tm3Paw mutation (0 available); any Nck2 mutation (29 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Assessment of atherosclerosis initiation and progression in tamoxifen-treated, high-fat diet fed Apoe^tm1Unc/Apoe^tm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw mice.

cardiovascular system

decreased susceptibility to diet-induced aortic fatty streak lesions ( J:326659 )

• severity of lesions, atherosclerosis progression, and macrophage recruitment are reduced in male, but not female, following 16 weeks of a high-fat diet in tamoxifen-treated mice

• however, serum lipoprotein levels are normal

immune system

decreased inflammatory response ( J:326659 )

• severity of lesions, atherosclerosis progression, and macrophage recruitment are reduced in male, but not female, following 16 weeks of a high-fat diet in tamoxifen-treated mice

Allelic Composition	Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw Tg(Nphs2-cre)1Seq/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nck1^tm1Paw mutation (2 available); any Nck1 mutation (40 available)
Nck2^tm3Paw mutation (0 available); any Nck2 mutation (29 available)
Tg(Nphs2-cre)1Seq mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:107630 )

• by 4 days of age, mutants are smaller than wild-type littermates; this is more apparent by 3 weeks of age

homeostasis/metabolism

albuminuria ( J:107630 )

• at 3.5 and 4.5 weeks of age, mutants show excessive amounts of albumin in their urine, indicating damage to the filtration barrier

renal/urinary system

albuminuria ( J:107630 )

• at 3.5 and 4.5 weeks of age, mutants show excessive amounts of albumin in their urine, indicating damage to the filtration barrier

abnormal podocyte morphology ( J:107630 )

• by 3.5 weeks of age, loss of podocytes is observed

abnormal podocyte foot process morphology ( J:107630 )

• at E16.5, differentiated foot processes are absent in mutant embryos

fused podocyte foot processes ( J:107630 )

• in 4-day old mutants, there is complete fusion of foot processes around the capillary loops of the glomeruli

abnormal renal glomerulus morphology ( J:107630 )

• by 3.5 weeks of age, focal sclerosis and other defects are observed in the glomeruli

glomerulosclerosis ( J:107630 )

• by 3.5 weeks of age, focal sclerosis is observed in the glomeruli

renal cast ( J:107630 )

• mutants have a buildup of proteinaceous material in the kidney tubules

abnormal glomerular filtration barrier function ( J:107630 )

• damaged glomerular filtration barrier

Allelic Composition	Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm1Paw/Nck2^tm3Paw Tg(Nes-cre)1Kln/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nck1^tm1Paw mutation (2 available); any Nck1 mutation (40 available)
Nck2^tm1Paw mutation (1 available); any Nck2 mutation (29 available)
Nck2^tm3Paw mutation (0 available); any Nck2 mutation (29 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:129166 )

• mice die within a few days of birth with empty stomachs likely due to suckling defects

• one mouse survived to P12 and was small, severely ataxic, and its hindlimbs respond to stimulation with rhythmic extension/flexion seizure-like activity

nervous system

abnormal axon guidance ( J:129166 )

• axons aberrantly re-cross the midline of the grey matter of the spinal cord

• interneurons aberrantly re-cross the midline of the spinal cord

abnormal brain commissure morphology ( J:129166 )

• reduced development of the posterior commissure noted at 12 weeks of age

abnormal spinal cord grey matter morphology ( J:129166 )

• axons aberrantly re-cross the midline of the grey matter of the spinal cord

abnormal spinal cord dorsal column morphology ( J:129166 )

• mice exhibit a shallow dorsal funiculus and does not widen in adulthood compared to controls

abnormal central pattern generator function ( J:129166 )

• mice exhibit synchronous firing of bilateral ventral motor neurons

behavior/neurological

ataxia ( J:129166 )

• one mouse survived to P12 and was small, severely ataxic, and its hindlimbs respond to stimulation with rhythmic extension/flexion seizure-like activity

abnormal gait ( J:129166 )

• mice exhibit a hoping gait that is maintained to adulthood

growth/size/body

decreased body size ( J:129166 )

• one mouse survived to P12 and was small, severely ataxic, and its hindlimbs respond to stimulation with rhythmic extension/flexion seizure-like activity

cellular

abnormal axon guidance ( J:129166 )

• axons aberrantly re-cross the midline of the grey matter of the spinal cord

• interneurons aberrantly re-cross the midline of the spinal cord

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