Phenotypes associated with this allele

• Allele Symbol: Pdlim2^tm1Gru
• Allele Name: targeted mutation 1, Michael J Grusby
• Allele ID: MGI:3623895
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdlim2^tm1Gru/Pdlim2^tm1Gru	Not Specified	MGI:3624364

Genotype
MGI:3624364

hm1

• Allelic Composition: Pdlim2^tm1Gru/Pdlim2^tm1Gru
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 1 physiology ( J:99108 )

• cultured Th1 cells from lymph nodes of null mice produce 2-4 fold higher amounts of Ifng compared to cells from wild-type when stimulated with anti-CD3 or Il12

increased interferon-gamma secretion ( J:99108 )

• spleen cells of mutants produce more Ifng after in vivo challenge than do cells from wild-type mice

increased susceptibility to bacterial infection ( J:99108 )

• when challenged with heat-killed L. monocytogenes, livers of mutant mice show greater numbers and larger focal accumulations of mononuclear cells infiltrating the liver than seen in wild-type livers

hematopoietic system

abnormal T-helper 1 physiology ( J:99108 )

• cultured Th1 cells from lymph nodes of null mice produce 2-4 fold higher amounts of Ifng compared to cells from wild-type when stimulated with anti-CD3 or Il12