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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm2Wahl
targeted mutation 2, Geoffrey M Wahl
MGI:3623943
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm2Wahl/Trp53tm2Wahl involves: 129S4/SvJae * C57BL/6 MGI:3714349
cx2
 		Mdm2tm1Glo/Mdm2+
Trp53tm2Wahl/Trp53tm2Wahl 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:5285192
cx3
 		Cdkn1atm1Hpw/Cdkn1a+
Trp53tm2Wahl/Trp53tm2Wahl 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5285193


Genotype
MGI:3714349
hm1
Allelic
Composition		 Trp53tm2Wahl/Trp53tm2Wahl
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2Wahl mutation (0 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:174375 )
N
• mice exhibit normal lifespan and aging
increased mortality induced by ionizing radiation ( J:174375 )
• all mice die within 4 weeks of irradiation unlike similarly treated wild-type mice

hematopoietic system
abnormal definitive hematopoiesis ( J:174375 )
• irradiated mice exhibit intra- and extramedullary hematopoiesis that does not compensate for pancytopenia unlike in wild-type mice
decreased common myeloid progenitor cell number ( J:174375 )
• irradiated mice exhibit a more severe decrease in granulocytic/macrophage (CFU-GM) compared with wild-type mice
decreased bone marrow cell number ( J:174375 )
• after irradiation, mice exhibit atrophy of hematopoietic cells in the bone marrow compared with similarly treated wild-type mice
decreased erythroid progenitor cell number ( J:174375 )
• irradiated mice exhibit a more severe decrease in erythroid (BFU-E) compared with wild-type mice
abnormal megakaryocyte progenitor cell morphology ( J:174375 )
• irradiated mice exhibit a more severe decrease in megakaryocytic (CFU-MK) compared with wild-type mice
decreased erythrocyte cell number ( J:174375 )
• slightly prior to irradiation
• after irradiation
decreased hematocrit ( J:174375 )
• in irradiated mice
thrombocytopenia ( J:174375 )
• slightly prior to irradiation
• after irradiation
decreased leukocyte cell number ( J:174375 )
• slightly prior to irradiation
• after irradiation
decreased spleen red pulp amount ( J:174375 )
• after irradiation
abnormal hematopoietic stem cell physiology ( J:174375 )
• hematopoietic stem cells compete poorly with wild-type cells in transplantation assays and are more sensitive to irradiation compared with wild-type cells

cardiovascular system
enlarged heart ( J:174375 )
• in irradiated mice
increased heart weight ( J:174375 )
• in irradiated mice

integument
pallor ( J:174375 )
• in irradiated mice

immune system
decreased leukocyte cell number ( J:174375 )
• slightly prior to irradiation
• after irradiation
decreased spleen red pulp amount ( J:174375 )
• after irradiation

homeostasis/metabolism
increased mortality induced by ionizing radiation ( J:174375 )
• all mice die within 4 weeks of irradiation unlike similarly treated wild-type mice

growth/size/body
enlarged heart ( J:174375 )
• in irradiated mice
increased heart weight ( J:174375 )
• in irradiated mice




Genotype
MGI:5285192
cx2
Allelic
Composition		 Mdm2tm1Glo/Mdm2+
Trp53tm2Wahl/Trp53tm2Wahl
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Trp53tm2Wahl mutation (0 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased mortality induced by ionizing radiation ( J:174375 )
• compared with Mdm2tm1Glo heterozygotes

hematopoietic system
small thymus ( J:174375 )
• compared with Trp53tm2Wahl homozygotes
decreased erythrocyte cell number ( J:174375 )
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
thrombocytopenia ( J:174375 )
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
decreased leukocyte cell number ( J:174375 )
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
spleen atrophy ( J:174375 )
• severe in irradiated-mice

skeleton
abnormal bone marrow morphology ( J:174375 )
• severe atrophic in irradiated-mice

immune system
small thymus ( J:174375 )
• compared with Trp53tm2Wahl homozygotes
decreased leukocyte cell number ( J:174375 )
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
spleen atrophy ( J:174375 )
• severe in irradiated-mice

homeostasis/metabolism
increased mortality induced by ionizing radiation ( J:174375 )
• compared with Mdm2tm1Glo heterozygotes

endocrine/exocrine glands
small thymus ( J:174375 )
• compared with Trp53tm2Wahl homozygotes




Genotype
MGI:5285193
cx3
Allelic
Composition		 Cdkn1atm1Hpw/Cdkn1a+
Trp53tm2Wahl/Trp53tm2Wahl
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Hpw mutation (1 available); any Cdkn1a mutation (63 available)
Trp53tm2Wahl mutation (0 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased mortality induced by ionizing radiation ( J:174375 )
• compared with irradiated Trp53tm2Wahl homozygotes

homeostasis/metabolism
decreased mortality induced by ionizing radiation ( J:174375 )
• compared with irradiated Trp53tm2Wahl homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory