mortality/aging
• homozygous embryos are viable until E14.5-15.5
|
cellular
• plated embryonic fibroblasts from mutants show a decreased ability to attach to fibronectin in a palladin dose-dependent manner
|
• fibroblasts from palladin-deficient mice show reduced motility compared to wild-type cells in a wound-healing assay
|
nervous system
• at E9.5, neural tube of mutants remains open from the midbrain to the hindbrain; mutants show herniation of the liver and intestine due to ventral closure defects
|
exencephaly
(
J:100650
)
embryo
• at E9.5, neural tube of mutants remains open from the midbrain to the hindbrain; mutants show herniation of the liver and intestine due to ventral closure defects
|