Phenotypes associated with this allele

• Allele Symbol: Espl1^tm1.1Tno
• Allele Name: targeted mutation 1.1, Tetsuo Noda
• Allele ID: MGI:3624002
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Espl1^tm1.1Tno/Espl1^+	involves: 129S4/SvJae * C57BL/6J	MGI:3714314
cn2	Espl1^tm1.1Tno/Espl1^tm1.2Tno	involves: 129S4/SvJae * C57BL/6J	MGI:3714319
cn3	Espl1^tm1.1Tno/Espl1^+ Pttg1^tm1.1Tno/Pttg1^tm1.1Tno	involves: 129S4/SvJae * C57BL/6J	MGI:3714315

Genotype
MGI:3714314

cn1

• Allelic Composition: Espl1^tm1.1Tno/Espl1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal chromosome morphology ( J:107917 )

• following Cre-adenovirus treatment, mouse embryonic fibroblast sister chromatids fail to separate at the centromere

Genotype
MGI:3714319

cn2

• Allelic Composition: Espl1^tm1.1Tno/Espl1^tm1.2Tno
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

cellular

abnormal cell nucleus morphology ( J:107917 )

• following treatment with Cre-adenovirus, mouse embryonic fibroblasts (MEFs) have enlarged nuclei

decreased cell proliferation ( J:107917 )

• following treatment with Cre-adenovirus, mouse embryonic fibroblasts (MEFs) exhibit growth retardation

• DNA replication continues to occur

• however, infection with Cre-adenovirus can reduce some growth in the absence of floxed alleles

Genotype
MGI:3714315

cn3

• Allelic Composition: Espl1^tm1.1Tno/Espl1⁺; Pttg1^tm1.1Tno/Pttg1^tm1.1Tno
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

cellular

decreased cell proliferation ( J:107917 )

• treatment with Cre-adenovirus severely restricts proliferation of mouse embryonic fibroblast cells

• however, there is no accumulation of DNA as seen in Espl1^tm1.1Tno/ Espl1^tm1.2Tno mice following Cre-adenovirus treatment

• however, infection with Cre-adenovirus can reduce some growth in the absence of floxed alleles