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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pttg1tm1.1Tno
targeted mutation 1.1, Tetsuo Noda
MGI:3624005
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Espl1tm1.1Tno/Espl1+
Pttg1tm1.1Tno/Pttg1tm1.1Tno 		involves: 129S4/SvJae * C57BL/6J MGI:3714315
cx2
 		Espl1tm1.2Tno/Espl1+
Pttg1tm1.1Tno/Pttg1tm1.1Tno 		involves: 129S4/SvJae * C57BL/6J MGI:3714317


Genotype
MGI:3714315
cn1
Allelic
Composition		 Espl1tm1.1Tno/Espl1+
Pttg1tm1.1Tno/Pttg1tm1.1Tno
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.1Tno mutation (0 available); any Espl1 mutation (95 available)
Pttg1tm1.1Tno mutation (0 available); any Pttg1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cell proliferation ( J:107917 )
• treatment with Cre-adenovirus severely restricts proliferation of mouse embryonic fibroblast cells
• however, there is no accumulation of DNA as seen in Espl1tm1.1Tno/ Espl1tm1.2Tno mice following Cre-adenovirus treatment
• however, infection with Cre-adenovirus can reduce some growth in the absence of floxed alleles




Genotype
MGI:3714317
cx2
Allelic
Composition		 Espl1tm1.2Tno/Espl1+
Pttg1tm1.1Tno/Pttg1tm1.1Tno
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.2Tno mutation (0 available); any Espl1 mutation (95 available)
Pttg1tm1.1Tno mutation (0 available); any Pttg1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:107917 )
• pups die prior to E12.5

growth/size/body
embryonic growth retardation ( J:107917 )

embryo




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory