Phenotypes associated with this allele

• Allele Symbol: Hipk2^tm1Hko
• Allele Name: targeted mutation 1, Haruhiko Koseki
• Allele ID: MGI:3624127
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hipk2^tm1Hko/Hipk2^tm1Hko	involves: C57BL/6	MGI:3624996
cx2	Hipk1^tm1Hko/Hipk1^tm1Hko Hipk2^tm1Hko/Hipk2^tm1Hko Trp53^tm2Mok/Trp53^+	involves: 129S/SvEv * C57BL/6	MGI:3625003
cx3	Hipk1^tm1Hko/Hipk1^tm1Hko Hipk2^tm1Hko/Hipk2^tm1Hko	involves: C57BL/6	MGI:3624999
cx4	Hipk1^tm1Hko/Hipk1^+ Hipk2^tm1Hko/Hipk2^tm1Hko	involves: C57BL/6	MGI:3625000
cx5	Hipk1^tm1Hko/Hipk1^tm1Hko Hipk2^tm1Hko/Hipk2^+	involves: C57BL/6	MGI:3625001

Genotype
MGI:3624996

hm1

• Allelic Composition: Hipk2^tm1Hko/Hipk2^tm1Hko
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:106931 )

• embryonic fibroblasts from null mice are slightly resistant to UV radiation compared to wild-type

• decreased numbers of apoptotic cells induced by UV irradiation are observed in MEFs compared to wild-type

nervous system

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

embryo

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

Genotype
MGI:3625003

cx2

• Allelic Composition: Hipk1^tm1Hko/Hipk1^tm1Hko; Hipk2^tm1Hko/Hipk2^tm1Hko; Trp53^tm2Mok/Trp53⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

nervous system

exencephaly ( J:106931 )

• four triple mutants were found to be exencephalic, whereas none were found to be wild-type for Trp53

Genotype
MGI:3624999

cx3

• Allelic Composition: Hipk1^tm1Hko/Hipk1^tm1Hko; Hipk2^tm1Hko/Hipk2^tm1Hko
• Genetic Background: involves: C57BL/6

mortality/aging

embryonic lethality during organogenesis ( J:106931 )

growth/size/body

embryonic growth retardation ( J:106931 )

• at E9.5, 14 of 17 live double homozygotes are smaller and developmentally delayed compared to Hipk1^tm1Kho homozygous or Hipk1^tm1Kho/Hipk1^tm1Kho Hipk2+/+ embryos

cellular

increased apoptosis ( J:106931 )

• significantly more apoptotic cells are observed in the condensing trigeminal and facioacoustic neural crest cells, as well as in the sclerotomal compartment, compared to Hipk1-null, Hipk2-wild-type mutants

decreased cell proliferation ( J:106931 )

• at E9.5, the frequency of mitotic cells in the cranial and caudal regions of the neural tube of double homozygotes is reduced to 45% and 29% compared to Hipk1-null, Hipk2 wild-type homozygotes

• proliferation of the cephalic mesoderm is reduced to 43% of that in Hipk1-null, Hipk2-wild-type double mutants

nervous system

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

exencephaly ( J:106931 )

• half of the homozygous embryos surviving to beyond E9.5 exhibit exencephaly

vision/eye

abnormal lens vesicle development ( J:106931 )

• in mutants lens vesicle formation fails with disorientation of the optic cups and fusion of the dorsal root ganglia

embryo

embryonic growth retardation ( J:106931 )

• at E9.5, 14 of 17 live double homozygotes are smaller and developmentally delayed compared to Hipk1^tm1Kho homozygous or Hipk1^tm1Kho/Hipk1^tm1Kho Hipk2+/+ embryos

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

Genotype
MGI:3625000

cx4

• Allelic Composition: Hipk1^tm1Hko/Hipk1⁺; Hipk2^tm1Hko/Hipk2^tm1Hko
• Genetic Background: involves: C57BL/6

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:106931 )

• about half of the mutants are lost during gestation, compared to the predicted number

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:106931 )

• embryonic fibroblasts from mutant mice are more resistant to UV radiation compared to single Hipk1 or Hipk2-null mice

• decreased numbers of apoptotic cells induced by UV irradiation are observed in MEFs compared to wild-type

nervous system

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

embryo

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

Genotype
MGI:3625001

cx5

• Allelic Composition: Hipk1^tm1Hko/Hipk1^tm1Hko; Hipk2^tm1Hko/Hipk2⁺
• Genetic Background: involves: C57BL/6

nervous system

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

exencephaly ( J:106931 )

• a small number of these mutants exhibit exencephaly

embryo

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants