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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Espl1tm1.2Kna
targeted mutation 1.2, Kim Nasmyth
MGI:3624201
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Espl1tm1.2Kna/Espl1tm1.2Kna involves: 129P2/OlaHsd * C57BL/6 MGI:3625273
cn2
Espl1tm1.1Kna/Espl1tm1.2Kna
Wapltm1.1Jmpt/Wapltm1.2Jmpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL MGI:5551815
cx3
Espl1tm1.2Kna/Espl1+
Pttg1tm1.2Kna/Pttg1tm1.2Kna
involves: 129P2/OlaHsd * C57BL/6 MGI:3625275


Genotype
MGI:3625273
hm1
Allelic
Composition
Espl1tm1.2Kna/Espl1tm1.2Kna
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.2Kna mutation (0 available); any Espl1 mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5551815
cn2
Allelic
Composition
Espl1tm1.1Kna/Espl1tm1.2Kna
Wapltm1.1Jmpt/Wapltm1.2Jmpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.1Kna mutation (0 available); any Espl1 mutation (95 available)
Espl1tm1.2Kna mutation (0 available); any Espl1 mutation (95 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Wapltm1.1Jmpt mutation (0 available); any Wapl mutation (169 available)
Wapltm1.2Jmpt mutation (0 available); any Wapl mutation (169 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• tamoxifen-treated mouse embryonic fibroblasts exhibit diplo-chromosomes with unseparated arms unlike in control cells




Genotype
MGI:3625275
cx3
Allelic
Composition
Espl1tm1.2Kna/Espl1+
Pttg1tm1.2Kna/Pttg1tm1.2Kna
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.2Kna mutation (0 available); any Espl1 mutation (95 available)
Pttg1tm1.2Kna mutation (0 available); any Pttg1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cellular
• at E9.5 larger, lobed nuclei are seen in several organs, including the somites, heart, and brain
• after 10 days in culture MEFs have large lobed nuclei
• 16 of 24 mitotic MEF cells had multipolar spindles and 8 were undergoing anaphase with lagging chromosomes
• 16 of 24 mitotic MEF cells had multipolar spindles
• extensive cell death is seen at E9.5

embryo
• irregular somites are seen at E10.5

nervous system

growth/size/body





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory