All Phenotypes Pttg1<tm1.2Kna> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pttg1^tm1.2Kna
targeted mutation 1.2, Kim Nasmyth
MGI:3624203

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pttg1^tm1.2Kna/Pttg1^tm1.2Kna	involves: 129P2/OlaHsd * C57BL/6	MGI:3625274
cx2	Espl1^tm1.2Kna/Espl1⁺ Pttg1^tm1.2Kna/Pttg1^tm1.2Kna	involves: 129P2/OlaHsd * C57BL/6	MGI:3625275

Allelic Composition	Pttg1^tm1.2Kna/Pttg1^tm1.2Kna
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pttg1^tm1.2Kna mutation (0 available); any Pttg1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reduced fertility ( J:107916 )

Allelic Composition	Espl1^tm1.2Kna/Espl1⁺ Pttg1^tm1.2Kna/Pttg1^tm1.2Kna
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1^tm1.2Kna mutation (0 available); any Espl1 mutation (95 available)
Pttg1^tm1.2Kna mutation (0 available); any Pttg1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:107916 )

• die at E11.5

cellular

abnormal cell nucleus morphology ( J:107916 )

• at E9.5 larger, lobed nuclei are seen in several organs, including the somites, heart, and brain

• after 10 days in culture MEFs have large lobed nuclei

abnormal mitosis ( J:107916 )

• 16 of 24 mitotic MEF cells had multipolar spindles and 8 were undergoing anaphase with lagging chromosomes

abnormal mitotic spindle morphology ( J:107916 )

• 16 of 24 mitotic MEF cells had multipolar spindles

abnormal cell death ( J:107916 )

• extensive cell death is seen at E9.5

embryo

decreased embryo size ( J:107916 )

• at E10.5

abnormal neural tube morphology ( J:107916 )

• at E10.5

abnormal somite development ( J:107916 )

• irregular somites are seen at E10.5

nervous system

abnormal neural tube morphology ( J:107916 )

• at E10.5

growth/size/body

decreased embryo size ( J:107916 )

• at E10.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24