Analysis Tools
endocrine/exocrine glands
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• reduced numbers of fat droplets are present in the epithelial cells of the mammary glands of mutants compared to wild-type
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• ducts of mammary glands in lactating homozygous female are underdeveloped compared to wild-type mice
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• alveoli of mammary glands in lactating homozygous female are underdeveloped compared to wild-type mice
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• amount of fat in the milk is reduced; in homozygous mutant females there is a decrease in the size and amount of lipid droplets in the alveoli and ducts of the mammary glands
• the amounts of diacylglycerols and triacylglycerols are reduced by 90% in the milk of homozygous females
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• pups from homozygous females die within 48 hours unless transferred to foster mothers; homozygous females have some capacity to make milk because newborn pups have a milk stripe
• rarely, pups that are nursed by homozygous females survive the early postnatal period but are always runts that die by 3-4 weeks of age
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integument
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• reduced numbers of fat droplets are present in the epithelial cells of the mammary glands of mutants compared to wild-type
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|
|
• ducts of mammary glands in lactating homozygous female are underdeveloped compared to wild-type mice
|
|
|
• alveoli of mammary glands in lactating homozygous female are underdeveloped compared to wild-type mice
|
|
|
• amount of fat in the milk is reduced; in homozygous mutant females there is a decrease in the size and amount of lipid droplets in the alveoli and ducts of the mammary glands
• the amounts of diacylglycerols and triacylglycerols are reduced by 90% in the milk of homozygous females
|
|
|
• pups from homozygous females die within 48 hours unless transferred to foster mothers; homozygous females have some capacity to make milk because newborn pups have a milk stripe
• rarely, pups that are nursed by homozygous females survive the early postnatal period but are always runts that die by 3-4 weeks of age
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