All Phenotypes Rb1<tm1.1Gfk> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rb1^tm1.1Gfk
targeted mutation 1.1, Graham F Kay
MGI:3624440

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rb1^tm1.1Gfk/Rb1^tm1.1Gfk Tg(Tyr-cre)1Gfk/0	involves: 129T2/SvEms * C57BL/6 * SJL	MGI:3624443

Allelic Composition	Rb1^tm1.1Gfk/Rb1^tm1.1Gfk Tg(Tyr-cre)1Gfk/0
Genetic Background	involves: 129T2/SvEms * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1^tm1.1Gfk mutation (0 available); any Rb1 mutation (111 available)
Tg(Tyr-cre)1Gfk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:108628 )

• occurring between 2 and 4 weeks of age

• eyes and skin are normal

pigmentation

abnormal melanocyte morphology ( J:108628 )

• decreased doubling time of melanocytes in culture

• slightly higher proportion of cells actively "cycling"

• cell proliferation not affected by deprivation of growth factors

• melanocytes in culture become depigmented by passage 19

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24