All Phenotypes Rb1<tm1.1Gfk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rb1^tm1.1Gfk
targeted mutation 1.1, Graham F Kay
MGI:3624440

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rb1^tm1.1Gfk/Rb1^tm1.1Gfk Tg(Tyr-cre)1Gfk/0	involves: 129T2/SvEms * C57BL/6 * SJL	MGI:3624443

Allelic Composition	Rb1^tm1.1Gfk/Rb1^tm1.1Gfk Tg(Tyr-cre)1Gfk/0
Genetic Background	involves: 129T2/SvEms * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1^tm1.1Gfk mutation (0 available); any Rb1 mutation (111 available)
Tg(Tyr-cre)1Gfk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:108628 )

• occurring between 2 and 4 weeks of age

• eyes and skin are normal

pigmentation

abnormal melanocyte morphology ( J:108628 )

• decreased doubling time of melanocytes in culture

• slightly higher proportion of cells actively "cycling"

• cell proliferation not affected by deprivation of growth factors

• melanocytes in culture become depigmented by passage 19

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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