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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
In(4)56Rk
inversion, Chr 4, Roderick 56
MGI:3624517
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
In(4)56Rk/In(4)56Rk involves: C57BL/6J * DBA/2J MGI:3624515
ht2
In(4)56Rk/+ involves: C57BL/6J * DBA/2J MGI:3624516


Genotype
MGI:3624515
hm1
Allelic
Composition
In(4)56Rk/In(4)56Rk
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(4)56Rk mutation (1 available); any In(4)56Rk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3624516
ht2
Allelic
Composition
In(4)56Rk/+
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(4)56Rk mutation (1 available); any In(4)56Rk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• optic atrophy appears in the fundus by 4 weeks of age
• retinal vessel attenuation appears in the fundus by 4 weeks of age
• pigment spots appear in the fundus by 4 weeks of age
• the outer nuclear layer begins to reduce at 10 days and is lost by 6 weeks of age
• layer begins to reduce at 10 days of age in mutants and is totally lost at 6 weeks
• by 2 weeks of age, the photoreceptor layer
• by 3 weeks of age, only cones are detected in mutants; by 6 weeks, there are no photoreceptors
• in mutants, the electroretinogram is never normal

nervous system
• by 3 weeks of age, only cones are detected in mutants; by 6 weeks, there are no photoreceptors

pigmentation
• pigment spots appear in the fundus by 4 weeks of age

cardiovascular system
• retinal vessel attenuation appears in the fundus by 4 weeks of age





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory