About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm2Emo
targeted mutation 2, Eugene M Oltz
MGI:3624531
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm2Emo/Ightm2Emo involves: 129S1/Sv * C57BL/6 * FVB/N MGI:3630305


Genotype
MGI:3630305
hm1
Allelic
Composition		 Ightm2Emo/Ightm2Emo
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Emo mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:108098 )
• homozygotes show a 10-fold decrease in proportion of B220+IgM+ cells demonstrating a block of B cell development
absent pre-B cells ( J:108098 )
• bone marrow of mice is severely deficient in pre-B cells compared to wild-type

hematopoietic system
abnormal B cell differentiation ( J:108098 )
• homozygotes show a 10-fold decrease in proportion of B220+IgM+ cells demonstrating a block of B cell development
absent pre-B cells ( J:108098 )
• bone marrow of mice is severely deficient in pre-B cells compared to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory