Analysis Tools
nervous system
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• in null mice, the rostral migratory stream appears thicker than in wild-type; rather than being a thin compact channel, the RMS appears more diffuse and covers a larger area
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• in cultures prepared from brains of E13.5 and 14.5 null and wild-type mice, branching of interneuron precursors is higher in cultures from brains of null mice
• interneuron precursors in null mice extend shorter branches and produce new branches at a higher frequency; new branches exist for a shorter time in Dcx-null animals
• nuclear movement during branching of interneuron precursors is abnormal in null mice; a variety of swelling types are observed, some of which are an appreciable distance from the nucleus and the size of the swellings is larger in null mice than in wild type
• frequency of swelling formation is decreased in mutants while the lifetime of swellings is increased compared to wild-type
• dynamics of nuclear movement are different in mutants vs wild-type with long nuclear displacements are 3-fold less frequent in a cell from a null animal
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| lissencephaly | DOID:0050453 |
OMIM:PS607432 |
J:108229 | |
