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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
sevr
severe runting
MGI:3624558
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
sevr/sevr C3H/HeJ-sevr/GrsrJ MGI:3697177


Genotype
MGI:3697177
hm1
Allelic
Composition
sevr/sevr
Genetic
Background
C3H/HeJ-sevr/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
sevr mutation (1 available); any sevr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Characterization of the sevr/sevr mouse

mortality/aging
• high mortality rate at approximately 4 weeks of age

behavior/neurological
• slight tremors are often seen before death

growth/size/body
• smaller body size by 2 weeks of age

hearing/vestibular/ear
N
• ABR thresholds are normal

hematopoietic system
• between 5 weeks and 4 months of age there is atrophy of the thymus typical of that in wasting mice

immune system
• between 5 weeks and 4 months of age there is atrophy of the thymus typical of that in wasting mice

vision/eye
N
• opthalmoscopic examination shows normal eyes at 3 weeks of age

endocrine/exocrine glands
• between 5 weeks and 4 months of age there is atrophy of the thymus typical of that in wasting mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory