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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cochtm1.1Stw
targeted mutation 1.1, Colin L Stewart
MGI:3624560
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cochtm1.1Stw/Cochtm1.1Stw CBACa.129S1-Cochtm1.1Stw MGI:4880749
hm2
 		Cochtm1.1Stw/Cochtm1.1Stw involves: 129S1/Sv MGI:3630341
hm3
 		Cochtm1.1Stw/Cochtm1.1Stw involves: 129S1/Sv * C57BL/6 * CD-1 MGI:3700754
ht4
 		Cochtm1.1Stw/Coch+ CBACa.129S1-Cochtm1.1Stw MGI:4880751


Genotype
MGI:4880749
hm1
Allelic
Composition		 Cochtm1.1Stw/Cochtm1.1Stw
Genetic
Background		 CBACa.129S1-Cochtm1.1Stw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cochtm1.1Stw mutation (2 available); any Coch mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:167669 )
N
• despite hearing and vestibular deficits, no gross abnormalities are seen in the cochlear duct or its accessory structures
increased or absent threshold for auditory brainstem response ( J:167669 )
• increased threshold or absent at the highest frequency test (41.2 Hz) at 21 months of age
reduced linear vestibular evoked potential ( J:167669 )
• increase in VsEP thresholds at 13 and 21 months of age




Genotype
MGI:3630341
hm2
Allelic
Composition		 Cochtm1.1Stw/Cochtm1.1Stw
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cochtm1.1Stw mutation (2 available); any Coch mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:105566 , J:108251 )
• surprisingly, homozygotes are viable and overtly normal and females display no defects in implantation or reproduction relative to wild-type littermates (J:105566)
• at ~5 months, homozygotes do not display any apparent inner ear histopathology or any significant hearing loss relative to wild-type mice (J:108251)




Genotype
MGI:3700754
hm3
Allelic
Composition		 Cochtm1.1Stw/Cochtm1.1Stw
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cochtm1.1Stw mutation (2 available); any Coch mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:116965 )
N
• at P19, 3- and 5- months of age, homozygotes exhibit no significant differences in auditory brainstem responses to click and pure-tone stimuli (8, 16, 32 kHz) relative to wild-type mice




Genotype
MGI:4880751
ht4
Allelic
Composition		 Cochtm1.1Stw/Coch+
Genetic
Background		 CBACa.129S1-Cochtm1.1Stw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cochtm1.1Stw mutation (2 available); any Coch mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:167669 )
N
• unlike in homozygous mutant mice, no hearing deficit is detected at any age
reduced linear vestibular evoked potential ( J:167669 )
• increase in VsEP thresholds at 21 months of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory