Phenotypes associated with this allele

• Allele Symbol: H6pd^tm1Pmst
• Allele Name: targeted mutation 1, Paul M Stewart
• Allele ID: MGI:3624665
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H6pd^tm1Pmst/H6pd^tm1Pmst	involves: 129P2/OlaHsd	MGI:3818041
hm2	H6pd^tm1Pmst/H6pd^tm1Pmst	involves: 129P2/OlaHsd * C57BL/6	MGI:3630345
cx3	H6pd^tm1Pmst/H6pd^tm1Pmst Hsd11b1^tm1.1Ggla/Hsd11b1^tm1.1Ggla	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5444447

Genotype
MGI:3818041

hm1

• Allelic Composition: H6pd^tm1Pmst/H6pd^tm1Pmst
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:141273 )

• microsomes from liver, adipose tissue or muscles lack oxo-reductase activity but exhibit increased dehydrogenase activity compared to in wild-type microsomes

abnormal response/metabolism to endogenous compounds ( J:141273 )

• mice fail to respond to treatment with 11-dehydrocorticosterone by decreasing glucose stimulated insulin secretion as do wild-type mice

• however, treatment with corticosterone decreases glucose stimulated insulin secretion normally

Genotype
MGI:3630345

hm2

• Allelic Composition: H6pd^tm1Pmst/H6pd^tm1Pmst
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

muscle

increased skeletal muscle glycogen level ( J:189132 )

• in some fibers

decreased quadriceps weight ( J:189132 )

• at 10 weeks

decreased tibialis anterior weight ( J:189132 )

• at 10 weeks

abnormal skeletal muscle fiber morphology ( J:189132 )

• vacuolated type fibers in quadriceps and tibialis anterior muscle

centrally nucleated skeletal muscle fibers ( J:189132 )

• in quadriceps and tibialis anterior muscle

skeletal muscle atrophy ( J:189132 )

• of the quadriceps and tibialis anterior muscle

homeostasis/metabolism

decreased circulating glucose level ( J:189132 )

• in fasted mice

decreased circulating corticosterone level ( J:108281 , J:189132 )

• basal (morning) plasma levels in knockouts are lower than in controls (J:108281)

increased skeletal muscle glycogen level ( J:189132 )

• in some fibers

abnormal enzyme/coenzyme activity ( J:108281 )

• intact hepatic microsomes show minimal 11Beta-HSD1 oxoreductase activity that cannot be stimulated by addition of glucose-6-phosphate; they display elevated Glc-6-P dehydrogenase activity compared to controls

growth/size/body

decreased lean body mass ( J:189132 )

• at 10 weeks, mice exhibit a decrease in quadriceps and tibialis anterior muscle compared with control mice

decreased body weight ( J:189132 )

• at 10 weeks

endocrine/exocrine glands

enlarged adrenal glands ( J:108281 , J:189132 )

• glands from male null mice are enlarged compared to wild-type (3.1g vs 1.9 g in wild-type) (J:108281)

• increased adrenal weight compared with wild-type Hsd11b1^tm1.1Ggla homozygotes and H6pd^tm1Pmst Hsd11b1^tm2.1Ggla double homozygotes (J:189132)

limbs/digits/tail

decreased quadriceps weight ( J:189132 )

• at 10 weeks

decreased tibialis anterior weight ( J:189132 )

• at 10 weeks

Genotype
MGI:5444447

cx3

• Allelic Composition: H6pd^tm1Pmst/H6pd^tm1Pmst; Hsd11b1^tm1.1Ggla/Hsd11b1^tm1.1Ggla
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

muscle

increased skeletal muscle glycogen level ( J:189132 )

• in some fibers

decreased quadriceps weight ( J:189132 )

• at 10 weeks

decreased tibialis anterior weight ( J:189132 )

• at 10 weeks

abnormal skeletal muscle fiber morphology ( J:189132 )

• vacuolated type fibers in quadriceps and tibialis anterior muscle

centrally nucleated skeletal muscle fibers ( J:189132 )

• in quadriceps and tibialis anterior muscle

skeletal muscle atrophy ( J:189132 )

• of the quadriceps and tibialis anterior muscle

growth/size/body

decreased lean body mass ( J:189132 )

• at 10 weeks, mice exhibit a decrease in quadriceps and tibialis anterior muscle compared with control mice

decreased body weight ( J:189132 )

• at 10 weeks

homeostasis/metabolism

decreased circulating glucose level ( J:189132 )

• in fasted mice

increased skeletal muscle glycogen level ( J:189132 )

• in some fibers

endocrine/exocrine glands

enlarged adrenal glands ( J:189132 )

• increased adrenal weight

limbs/digits/tail

decreased quadriceps weight ( J:189132 )

• at 10 weeks

decreased tibialis anterior weight ( J:189132 )

• at 10 weeks