Phenotypes associated with this allele

• Allele Symbol: Mpp4^tm1Wij
• Allele Name: targeted mutation 1, Jan Wijnholds
• Allele ID: MGI:3624689
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mpp4^tm1Wij/Mpp4^tm1Wij	involves: 129P2/OlaHsd * C57BL/6	MGI:3629295

Genotype
MGI:3629295

hm1

• Allelic Composition: Mpp4^tm1Wij/Mpp4^tm1Wij
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal plasma membrane morphology ( J:108232 )

• in Mpp4-deficient mice, Psd95 is not present at presynaptic vesicles or at the plasma membrane of rod and cone synapses

vision/eye

abnormal retina morphology ( J:108232 )

• retina of mutant develops normally up to 12 months of age except for sporadically displaced photoreceptors

• in 3 month-old mutants exposed to 3000 lux white light for 3 days, small areas of photoreceptor displacement are observed in some animals; this is not observed at 1 month of age or at 6 and 12 months of age without light exposure