Phenotypes associated with this allele

• Allele Symbol: Aqp2^tm1Nlsn
• Allele Name: targeted mutation 1, Soren Nielsen
• Allele ID: MGI:3624696
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Aqp2^tm1Nlsn/Aqp2^tm1Nlsn Tg(Hoxb7-cre)13Amc/0	involves: 129/Sv * C57BL/6	MGI:3626345

Genotype
MGI:3626345

cn1

• Allelic Composition: Aqp2^tm1Nlsn/Aqp2^tm1Nlsn; Tg(Hoxb7-cre)13Amc/0
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:108291 )

• partial penetrance

renal/urinary system

decreased urine osmolality ( J:108291 )

• osmolality is only 170 +/- 19 milliosmoles/kg of water compared to 1630 +/- 135 milliosmoles/kg of water for wild-type mice

• water deprivation does not increase urine osmolality

kidney papillary atrophy ( J:108291 )

• variable progressive papillary atrophy in those that survive past weaning

hydronephrosis ( J:108291 )

• variable progressive hydronephrosis in those that survive past weaning

polyuria ( J:108291 )

• about a 10-fold increase in urine output

• water deprivation results in only a marginal decrease in urine output

homeostasis/metabolism

decreased urine osmolality ( J:108291 )

• osmolality is only 170 +/- 19 milliosmoles/kg of water compared to 1630 +/- 135 milliosmoles/kg of water for wild-type mice

• water deprivation does not increase urine osmolality