All Phenotypes Nle1<tm1Cba> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nle1^tm1Cba/Nle1^tm1Cba	involves: 129S2/SvPas * C57BL/6 * SJL/J	MGI:3626287
cn2	Nle1^tm1Cba/Nle1^tm1.1Cota Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:5553371
cn3	Nle1^tm1Cba/Nle1^tm1.1Cota Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:5553372
cn4	Nle1^tm1Cba/Nle1^tm1.1Cota Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:5553374

Allelic Composition	Nle1^tm1Cba/Nle1^tm1Cba
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nle1^tm1Cba mutation (0 available); any Nle1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:108385 )

• died around E5.5 - E6.5

embryo

abnormal inner cell mass apoptosis ( J:108385 )

• the inner cell mass fails to expand and displays a significant increase in the number of apoptotic cells, but no change in cell proliferation

• however, no change in the number of trophectodermal cells is detected

failure of blastocyst to hatch from the zona pellucida ( J:108385 )

• most (17 of 21) blastocysts fail to hatch out of the zona pellucida after 3 days in culture

cellular

abnormal inner cell mass apoptosis ( J:108385 )

• the inner cell mass fails to expand and displays a significant increase in the number of apoptotic cells, but no change in cell proliferation

• however, no change in the number of trophectodermal cells is detected

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Severe hypocellularity in Nle1^tm1Cba/Nle1^tm1.1Cota Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ bone marrow, with capillaries saturated with erythrocytes

mortality/aging

premature death ( J:204063 )

• mice die 10 to 13 days after tamoxifen treatment

immune system

decreased granulocyte number ( J:204063 )

• in tamoxifen-treated mice

decreased NK cell number ( J:204063 )

• in tamoxifen-treated mice

decreased T cell number ( J:204063 )

• in tamoxifen-treated mice

decreased macrophage cell number ( J:204063 )

• in tamoxifen-treated mice

abnormal immune system organ morphology ( J:204063 )

• defects in secondary lymphoid organs in tamoxifen-treated mice

thymus hypoplasia ( J:204063 )

• in tamoxifen-treated mice

spleen hypoplasia ( J:204063 )

• in tamoxifen-treated mice

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:204063 )

• 7 to 9 days after tamoxifen treatment

cellular

abnormal ribosome biogenesis ( J:204063 )

• tamoxifen-treated mice exhibit impaired biogenesis of large ribosomal subunit in hematopoietic stem cell and multipotent progenitor compared with control mice

hematopoietic system

hematopoietic system phenotype ( J:204063 )

N	• hematopoietic stem cell mobilization occurs normally in tamoxifen-treated mice

thymus hypoplasia ( J:204063 )

• in tamoxifen-treated mice

impaired hematopoiesis ( J:204063 )

• tamoxifen-treated mice exhibit cell autonomous defects in hematopoiesis

abnormal bone marrow cell morphology/development ( J:204063 )

• in tamoxifen-treated mice

• tamoxifen-treated mice exhibit impaired biogenesis of large ribosomal subunit in hematopoietic stem cell and multipotent progenitor compared with control mice

decreased common myeloid progenitor cell number ( J:204063 )

• in tamoxifen-treated mice

decreased bone marrow cell number ( J:204063 )

• severe in tamoxifen-treated mice

abnormal common lymphocyte progenitor cell morphology ( J:204063 )

• decreased in tamoxifen-treated mice

decreased granulocyte number ( J:204063 )

• in tamoxifen-treated mice

decreased NK cell number ( J:204063 )

• in tamoxifen-treated mice

decreased T cell number ( J:204063 )

• in tamoxifen-treated mice

decreased macrophage cell number ( J:204063 )

• in tamoxifen-treated mice

spleen hypoplasia ( J:204063 )

• in tamoxifen-treated mice

abnormal hematopoietic stem cell physiology ( J:204063 )

• reduced hematopoietic stem cell and multipotent progenitor quiescence in tamoxifen-treated mice

endocrine/exocrine glands

thymus hypoplasia ( J:204063 )

• in tamoxifen-treated mice

Allelic Composition	Nle1^tm1Cba/Nle1^tm1.1Cota Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Nle1^tm1.1Cota mutation (0 available); any Nle1 mutation (27 available)
Nle1^tm1Cba mutation (0 available); any Nle1 mutation (27 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:204063 )

N	• tamoxifen-treated mice exhibit rescued total bone marrow and LSK cells

Allelic Composition	Nle1^tm1Cba/Nle1^tm1.1Cota Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Nle1^tm1.1Cota mutation (0 available); any Nle1 mutation (27 available)
Nle1^tm1Cba mutation (0 available); any Nle1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:204063 )

N	• mice exhibit normal numbers of bone marrow pre-B cells, immature B cells and splenic mature B cells • mice exhibit normal survival, proliferation and maturation of restricted progenitors

immune system

immune system phenotype ( J:204063 )

N	• mice exhibit normal numbers of bone marrow pre-B cells, immature B cells and splenic mature B cells • mice exhibit normal survival, proliferation and maturation of restricted progenitors

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