All Phenotypes Nle1<tm1Cba> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nle1^tm1Cba/Nle1^tm1Cba	involves: 129S2/SvPas * C57BL/6 * SJL/J	MGI:3626287
cn2	Nle1^tm1Cba/Nle1^tm1.1Cota Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:5553371
cn3	Nle1^tm1Cba/Nle1^tm1.1Cota Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:5553372
cn4	Nle1^tm1Cba/Nle1^tm1.1Cota Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:5553374

Allelic Composition	Nle1^tm1Cba/Nle1^tm1Cba
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nle1^tm1Cba mutation (0 available); any Nle1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:108385 )

• died around E5.5 - E6.5

embryo

abnormal inner cell mass apoptosis ( J:108385 )

• the inner cell mass fails to expand and displays a significant increase in the number of apoptotic cells, but no change in cell proliferation

• however, no change in the number of trophectodermal cells is detected

failure of blastocyst to hatch from the zona pellucida ( J:108385 )

• most (17 of 21) blastocysts fail to hatch out of the zona pellucida after 3 days in culture

cellular

abnormal inner cell mass apoptosis ( J:108385 )

• the inner cell mass fails to expand and displays a significant increase in the number of apoptotic cells, but no change in cell proliferation

• however, no change in the number of trophectodermal cells is detected

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Severe hypocellularity in Nle1^tm1Cba/Nle1^tm1.1Cota Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ bone marrow, with capillaries saturated with erythrocytes

mortality/aging

premature death ( J:204063 )

• mice die 10 to 13 days after tamoxifen treatment

immune system

decreased granulocyte number ( J:204063 )

• in tamoxifen-treated mice

decreased NK cell number ( J:204063 )

• in tamoxifen-treated mice

decreased T cell number ( J:204063 )

• in tamoxifen-treated mice

decreased macrophage cell number ( J:204063 )

• in tamoxifen-treated mice

abnormal immune system organ morphology ( J:204063 )

• defects in secondary lymphoid organs in tamoxifen-treated mice

thymus hypoplasia ( J:204063 )

• in tamoxifen-treated mice

spleen hypoplasia ( J:204063 )

• in tamoxifen-treated mice

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:204063 )

• 7 to 9 days after tamoxifen treatment

cellular

abnormal ribosome biogenesis ( J:204063 )

• tamoxifen-treated mice exhibit impaired biogenesis of large ribosomal subunit in hematopoietic stem cell and multipotent progenitor compared with control mice

hematopoietic system

hematopoietic system phenotype ( J:204063 )

N	• hematopoietic stem cell mobilization occurs normally in tamoxifen-treated mice

thymus hypoplasia ( J:204063 )

• in tamoxifen-treated mice

impaired hematopoiesis ( J:204063 )

• tamoxifen-treated mice exhibit cell autonomous defects in hematopoiesis

abnormal bone marrow cell morphology/development ( J:204063 )

• in tamoxifen-treated mice

• tamoxifen-treated mice exhibit impaired biogenesis of large ribosomal subunit in hematopoietic stem cell and multipotent progenitor compared with control mice

decreased common myeloid progenitor cell number ( J:204063 )

• in tamoxifen-treated mice

decreased bone marrow cell number ( J:204063 )

• severe in tamoxifen-treated mice

abnormal common lymphocyte progenitor cell morphology ( J:204063 )

• decreased in tamoxifen-treated mice

decreased granulocyte number ( J:204063 )

• in tamoxifen-treated mice

decreased NK cell number ( J:204063 )

• in tamoxifen-treated mice

decreased T cell number ( J:204063 )

• in tamoxifen-treated mice

decreased macrophage cell number ( J:204063 )

• in tamoxifen-treated mice

spleen hypoplasia ( J:204063 )

• in tamoxifen-treated mice

abnormal hematopoietic stem cell physiology ( J:204063 )

• reduced hematopoietic stem cell and multipotent progenitor quiescence in tamoxifen-treated mice

endocrine/exocrine glands

thymus hypoplasia ( J:204063 )

• in tamoxifen-treated mice

Allelic Composition	Nle1^tm1Cba/Nle1^tm1.1Cota Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Nle1^tm1.1Cota mutation (0 available); any Nle1 mutation (27 available)
Nle1^tm1Cba mutation (0 available); any Nle1 mutation (27 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:204063 )

N	• tamoxifen-treated mice exhibit rescued total bone marrow and LSK cells

Allelic Composition	Nle1^tm1Cba/Nle1^tm1.1Cota Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Nle1^tm1.1Cota mutation (0 available); any Nle1 mutation (27 available)
Nle1^tm1Cba mutation (0 available); any Nle1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:204063 )

N	• mice exhibit normal numbers of bone marrow pre-B cells, immature B cells and splenic mature B cells • mice exhibit normal survival, proliferation and maturation of restricted progenitors

immune system

immune system phenotype ( J:204063 )

N	• mice exhibit normal numbers of bone marrow pre-B cells, immature B cells and splenic mature B cells • mice exhibit normal survival, proliferation and maturation of restricted progenitors

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24