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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgb1tm1Mlkn
targeted mutation 1, Mark L Kahn
MGI:3624804
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itgb1tm1Mlkn/Itgb1tm1Mlkn involves: 129/Sv * C57BL/6 * SJL MGI:3639577


Genotype
MGI:3639577
hm1
Allelic
Composition		 Itgb1tm1Mlkn/Itgb1tm1Mlkn
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm1Mlkn mutation (0 available); any Itgb1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:108331 )
• no live homozygotes are detected at E6.5; homozygous embryos are resorbed, with only a residual population of trophoblast cells visible

embryo
absent inner cell mass ( J:108331 )
• at E6.5, embryos fail to develop an inner cell mass: embryos are identified by presence of persistent trophoblastic cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory