About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgb1tm3Mlkn
targeted mutation 3, Mark L Kahn
MGI:3624806
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Itgb1tm3Mlkn/Itgb1tm3Mlkn
Tg(Mx1-cre)1Cgn/0 		involves: 129/Sv * C57BL/6 * CBA MGI:3639582


Genotype
MGI:3639582
cn1
Allelic
Composition		 Itgb1tm3Mlkn/Itgb1tm3Mlkn
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm3Mlkn mutation (0 available); any Itgb1 mutation (60 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating noradrenaline level ( J:108331 )
• after ADP stimulation, platelets fail to bind soluble collagen in an inside-out activation assay
• severely defective platelet adhesion to collagen under flow is observed in mutants in an outside-in activation assay




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory