All Phenotypes Ptprn<tm1Aln> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprn^tm1Aln/Ptprn^tm1Aln	involves: 129S4/SvJae * C57BL/6	MGI:3626094
hm2	Ptprn^tm1Aln/Ptprn^tm1Aln	NOD.129S4-Ptprn^tm1Aln	MGI:3626090
cx3	Ptprn^tm1Aln/Ptprn^tm1Aln Ptprn2^tm1Aln/Ptprn2^tm1Aln	involves: 129S4/SvJae * C57BL/6N	MGI:6850117

Allelic Composition	Ptprn^tm1Aln/Ptprn^tm1Aln
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprn^tm1Aln mutation (0 available); any Ptprn mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired glucose tolerance ( J:108765 )

• diabetic Ptprn-deficient mice and wild-type mice display insulitis

Allelic Composition	Ptprn^tm1Aln/Ptprn^tm1Aln
Genetic Background	NOD.129S4-Ptprn^tm1Aln

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprn^tm1Aln mutation (0 available); any Ptprn mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

insulitis ( J:107161 )

• diabetic Ptprn-deficient NOD mice and wild-type NOD mice display insulitis

increased susceptibility to autoimmune diabetes ( J:107161 )

• 36.4% of NOD mice deficient for Ptprn develop diabetes as determined by 2 consecutive blood glucose levels above 250 mg/dl by 28 weeks of age while 44.4% of NOD wild-type mice develop diabetes

• 5 Ptprn-deficient mice show spontaneous diabetes between 20 and 40 weeks of age

endocrine/exocrine glands

insulitis ( J:107161 )

• diabetic Ptprn-deficient NOD mice and wild-type NOD mice display insulitis

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:129445 )

N	• double knockout male mice are fertile, unlike double mutant females; no alterations in testis histology or testis weight are observed at 12 weeks of age

abnormal ovary morphology ( J:129445 )

• lipid droplets are found in stromal cells at 7 weeks of age

• however, the number and appearance of oocytes and antral follicles is normal

absent corpus luteum ( J:129445 )

• corpora lutea are absent at 7 weeks and at 3 months of age

• however, large numbers of corpora lutea are formed within 96 h after PMSG + hCG treatment; hCG alone is not as effective as PMSG + hCG treatment

abnormal ovulation ( J:129445 )

• the typical LH surge required for ovulation is not observed at any of the times (i.e. daily) tested, unlike in wild-type controls

abnormal estrous cycle ( J:129445 )

• vaginal smears revealed total absence of a normal estrous cycle

female infertility ( J:129445 )

• double knockout females are essentially infertile, unlike single knockout females

• when mated with wild-type males, only 2 of 12 double knockout females produce offspring

decreased litter size ( J:129445 )

• when mated with wild-type males, only 2 of 12 double knockout females give birth and litter sizes are very small

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:129445 )

N	• double knockout male mice show normal plasma LH and FSH levels at 4 months of age • Western blot analysis revealed a non-significant (34%) reduction in the concentration of LH in pituitary lysates at 4 months of age

decreased follicle stimulating hormone level ( J:129445 )

• at 4 months of age, Western blot analysis revealed a 60% reduction in the concentration of FSH in pituitary lysates at proestrus

• however, basal FSH levels in the plasma are normal

decreased luteinizing hormone level ( J:129445 )

• at 4 months of age, Western blot analysis revealed a nearly 75% reduction in the concentration of LH in pituitary lysates at proestrus

• however, the concentration of LH is almost normal in pituitary lysates of pre-pubertal mice at 24 days of age

decreased circulating luteinizing hormone level ( J:129445 )

• no typical LH surge is found in plasma during proestrus at 3-6 months of age, unlike in wild-type controls