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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cadm1tm1Mrkm
targeted mutation 1, Yoshinori Murakami
MGI:3625113
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cadm1tm1Mrkm/Cadm1tm1Mrkm involves: 129S6/SvEvTac * C57BL/6J MGI:3626073


Genotype
MGI:3626073
hm1
Allelic
Composition		 Cadm1tm1Mrkm/Cadm1tm1Mrkm
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadm1tm1Mrkm mutation (0 available); any Cadm1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:108395 )
• the number of sperm in the semen was approximately 0.01% of wild-type
teratozoospermia ( J:108395 )
• almost all sperm from mutant mice showed abnormal morphologies, such as large round heads, short tails, and multiple tails
multiflagellated sperm ( J:108395 )
• multiple sperm tails
short sperm flagellum ( J:108395 )
• short sperm tails
globozoospermia ( J:108395 )
• large round sperm heads
decreased testis weight ( J:108395 )
• the weight of a testis was 88% that in wild-type mice
arrest of spermatogenesis ( J:108395 )
• maturation of the spermatids was arrested around step 10
• considerable number of spermatocytes and spermatids in mutant mice were apoptotic
male infertility ( J:108395 )
• no offspring ever resulted from mating between homozygous male and wild-type female
• a defect in fertility was not observed in female

endocrine/exocrine glands
decreased testis weight ( J:108395 )
• the weight of a testis was 88% that in wild-type mice

cellular
oligozoospermia ( J:108395 )
• the number of sperm in the semen was approximately 0.01% of wild-type
teratozoospermia ( J:108395 )
• almost all sperm from mutant mice showed abnormal morphologies, such as large round heads, short tails, and multiple tails
multiflagellated sperm ( J:108395 )
• multiple sperm tails
short sperm flagellum ( J:108395 )
• short sperm tails
globozoospermia ( J:108395 )
• large round sperm heads




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory