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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gfra4tm1Msa
targeted mutation 1, Matti S Airaksinen
MGI:3625130
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gfra4tm1Msa/Gfra4tm1Msa B6JHsd.129-Gfra4tm1Msa MGI:3628648
hm2
 		Gfra4tm1Msa/Gfra4tm1Msa involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd MGI:3628647


Genotype
MGI:3628648
hm1
Allelic
Composition		 Gfra4tm1Msa/Gfra4tm1Msa
Genetic
Background		 B6JHsd.129-Gfra4tm1Msa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra4tm1Msa mutation (0 available); any Gfra4 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:108404 )
N
• no difference in thyroid calcitonin level in adult
• Background Sensitivity: thyroid tissue calcitonin content was not significantly different in newborn mutant mice in B6 background compared to wild-type control




Genotype
MGI:3628647
hm2
Allelic
Composition		 Gfra4tm1Msa/Gfra4tm1Msa
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra4tm1Msa mutation (0 available); any Gfra4 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased bone mineralization ( J:108404 )
• display a greater mineral apposition rate
increased bone ossification ( J:108404 )
• display a greater bone formation rate

endocrine/exocrine glands
abnormal thyroid gland physiology ( J:108404 )
• no difference in thyroid calcitonin level in adult
• Background Sensitivity: thyroid tissue calcitonin content was reduced by 80% in newborn mutant mice in 129/B6 hybrid background compared to wild-type control




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory