Phenotypes associated with this allele

• Allele Symbol: Slc39a1^tm1.1Gka
• Allele Name: targeted mutation 1.1, Glen K Andrews
• Allele ID: MGI:3625131
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc39a1^tm1.1Gka/Slc39a1^tm1.1Gka	involves: 129X1/SvJ * C57BL/6 * FVB/N	MGI:3625155
cx2	Slc39a1^tm1.1Gka/Slc39a1^tm1.1Gka Slc39a3^tm1.1Gka/Slc39a3^tm1.1Gka	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3625156

Genotype
MGI:3625155

hm1

• Allelic Composition: Slc39a1^tm1.1Gka/Slc39a1^tm1.1Gka
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo development ( J:108627 )

• when dams are fed a zinc-deficient diet (<1 ppm Zn) from day E8, 45% of homozygous mutant embryos exhibit gross abnormalities at day E14, vs. 13.3% (this study; literature values = 13-23%) of wild-type embryos

embryonic growth retardation ( J:108627 )

• of the abnormal embryos of both mutant and wild-type zinc-deprived dams, approximately two-thirds are mildly affected (exhibiting growth retardation and delayed limb development)

• of the abnormal embryos of both mutant and wild-type zinc-deprived dams, approximately one-third are severely affected (having craniofacial defects in addition to severe retardation of both growth and development)

growth/size/body

embryonic growth retardation ( J:108627 )

• of the abnormal embryos of both mutant and wild-type zinc-deprived dams, approximately two-thirds are mildly affected (exhibiting growth retardation and delayed limb development)

• of the abnormal embryos of both mutant and wild-type zinc-deprived dams, approximately one-third are severely affected (having craniofacial defects in addition to severe retardation of both growth and development)

limbs/digits/tail

abnormal limb development ( J:108627 )

• of the abnormal embryos of both mutant and wild-type zinc-deprived dams, approximately two-thirds are mildly affected (exhibiting growth retardation and delayed limb development)

craniofacial

abnormal craniofacial development ( J:108627 )

• of the abnormal embryos of both mutant and wild-type zinc-deprived dams, approximately one-third are severely affected (having craniofacial defects in addition to severe retardation of both growth and development)

Genotype
MGI:3625156

cx2

• Allelic Composition: Slc39a1^tm1.1Gka/Slc39a1^tm1.1Gka; Slc39a3^tm1.1Gka/Slc39a3^tm1.1Gka
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

embryo

abnormal embryo development ( J:108627 )

• 91% of E14 homozygous doubly mutant embryos of dams fed a zinc-deficient diet (<1 ppm Zn) from day E8 are grossly abnormal

embryonic growth retardation ( J:108627 )

• of the abnormal embryos of zinc-deprived doubly mutant dams, the majority (54%) are severely affected, exhibiting craniofacial defects and dramatic retardation of both growth and development

• doubly mutant zinc-deprived E14 embryos classified as mildly affected, i.e., growth retarded with delayed limb development, often have formed no digits on the hind- or forelimbs

growth/size/body

embryonic growth retardation ( J:108627 )

• of the abnormal embryos of zinc-deprived doubly mutant dams, the majority (54%) are severely affected, exhibiting craniofacial defects and dramatic retardation of both growth and development

• doubly mutant zinc-deprived E14 embryos classified as mildly affected, i.e., growth retarded with delayed limb development, often have formed no digits on the hind- or forelimbs

limbs/digits/tail

abnormal limb development ( J:108627 )

• doubly mutant zinc-deprived E14 embryos classified as mildly affected, i.e., growth retarded with delayed limb development, often have formed no digits on the hind- or forelimbs

craniofacial

abnormal craniofacial development ( J:108627 )

• of the abnormal embryos of zinc-deprived doubly mutant dams, the majority (54%) are severely affected, exhibiting craniofacial defects and dramatic retardation of both growth and development

integument

blistering ( J:108627 )

• doubly mutant zinc-deprived E14 embryos classified as mildly affected, i.e., small with delayed limb development, often exhibit a dorsal skin blister; this effect is not observed in wild-type or either singly mutant zinc-deprived embryos