Phenotypes associated with this allele

• Allele Symbol: Arid3b^tm1Take
• Allele Name: targeted mutation 1, Takumi Era
• Allele ID: MGI:3625143
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arid3b^tm1Take/Arid3b^tm1Take	B6.Cg-Arid3b^tm1Take	MGI:3625993

Genotype
MGI:3625993

hm1

• Allelic Composition: Arid3b^tm1Take/Arid3b^tm1Take
• Genetic Background: B6.Cg-Arid3b^tm1Take

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:108390 )

• heterozygotes mating produced no live born homozygous pups

• homozygous mutants rarely survived to 12.5 dpc

cardiovascular system

abnormal vascular regression ( J:108390 )

• approximately 60% of homozygous mutant embryos with more severe phenotype showed abnormalities in their cardiovascular system

• this group had impaired vascular remodeling from the primitive plexus to the higher order architecture

abnormal heart development ( J:108390 )

• this group had arrested heart looping with dilated pericardial sacs

dilated heart ( J:108390 )

• approximately 60% of homozygous mutant embryos with more severe phenotype showed dilated hearts at 9.5-10.5 dpc

craniofacial

small pharyngeal arch ( J:108390 )

• approximately 60% of homozygous mutant embryos with more severe phenotype showed small and hypoplastic branchial arches at 9.5-10.5 dpc

cellular

abnormal vascular regression ( J:108390 )

• approximately 60% of homozygous mutant embryos with more severe phenotype showed abnormalities in their cardiovascular system

• this group had impaired vascular remodeling from the primitive plexus to the higher order architecture

increased apoptosis ( J:108390 )

• approximately 60% of homozygous mutant embryos with more severe phenotype showed extensive increase of apoptotic cells in both neural crest cell complex and branchial arches 1 and 2

embryo

small pharyngeal arch ( J:108390 )

• approximately 60% of homozygous mutant embryos with more severe phenotype showed small and hypoplastic branchial arches at 9.5-10.5 dpc

embryonic growth retardation ( J:108390 )

• about 40% of homozygous mutant embryos showed only growth retardation without cardiac and head deformities

wavy neural tube ( J:108390 )

• approximately 60% of homozygous mutant embryos with more severe phenotype showed wavy neural tube at 9.5 to 10.5 dpc

nervous system

wavy neural tube ( J:108390 )

• approximately 60% of homozygous mutant embryos with more severe phenotype showed wavy neural tube at 9.5 to 10.5 dpc

growth/size/body

embryonic growth retardation ( J:108390 )

• about 40% of homozygous mutant embryos showed only growth retardation without cardiac and head deformities

abnormal head morphology ( J:108390 )

• approximately 60% of homozygous mutant embryos with more severe phenotype showed head deformities with a small craniofacial structure at 9.5-10.5 dpc

• this group had a marked reduction in the number of mesenchymal cells putatively derived from neural fold