Phenotypes associated with this allele

• Allele Symbol: Cadm1^tm1.2Brd
• Allele Name: targeted mutation 1.2, Allan Bradley
• Allele ID: MGI:3625158
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cadm1^tm1.2Brd/Cadm1^tm1.2Brd	involves: 129S7/SvEvBrd	MGI:5585186
hm2	Cadm1^tm1.2Brd/Cadm1^tm1.2Brd	involves: 129S7/SvEvBrd * C57BL/6	MGI:3625931

Genotype
MGI:5585186

hm1

• Allelic Composition: Cadm1^tm1.2Brd/Cadm1^tm1.2Brd
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:210552 )

N • total pancreatic mass is normal

increased pancreatic beta cell proliferation ( J:210552 )

increased pancreatic beta cell mass ( J:210552 )

increased pancreatic beta cell number ( J:210552 )

cellular

increased pancreatic beta cell proliferation ( J:210552 )

Genotype
MGI:3625931

hm2

• Allelic Composition: Cadm1^tm1.2Brd/Cadm1^tm1.2Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

cellular

oligozoospermia ( J:108386 )

♂ • significantly reduced sperm count

teratozoospermia ( J:108386 )

♂ • the surviving spermatozoa were immature, malformed

asthenozoospermia ( J:108386 )

♂ • the majority of sperm were static

reproductive system

oligozoospermia ( J:108386 )

♂ • significantly reduced sperm count

teratozoospermia ( J:108386 )

♂ • the surviving spermatozoa were immature, malformed

asthenozoospermia ( J:108386 )

♂ • the majority of sperm were static

arrest of spermatogenesis ( J:108386 )

♂ • a nearly complete block in maturation at the spermatid stage of spermatogenesis

male infertility ( J:108386 )

♂ • no offspring ever resulted from mating between homozygous male and wild-type female

♂ • a defect in fertility was not observed in female

♂ • did not show decreased survival or an increased incidence of spontaneous tumor