Phenotypes associated with this allele

• Allele Symbol: Cd248^tm1Huso
• Allele Name: targeted mutation 1, David L Huso
• Allele ID: MGI:3625491
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd248^tm1Huso/Cd248^tm1Huso	involves: 129S/SvEv * C57BL/6	MGI:3626285

Genotype
MGI:3626285

hm1

• Allelic Composition: Cd248^tm1Huso/Cd248^tm1Huso
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor growth/size ( J:107172 )

• tumor fragments implanted on the serosal surface of the large intestine show reduced growth and fail to penetrate the inner layers of the intestine

• on a background that is also nude and immunodeficient, growth of implanted abdominal or intestinal tumors is reduced compared to wild-type mice; however, no difference in growth of implanted subcutaneous tumors is seen

• the number of small blood vessels (less than 50 um in diameter) in implanted intestinal tumors is significantly increased

immune system

immune system phenotype ( J:107172 )

N • wound healing is similar to wild-type mice