Phenotypes associated with this allele

• Allele Symbol: Adam11^tm1Sag
• Allele Name: targeted mutation 1, Koji Sagane
• Allele ID: MGI:3625523
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam11^tm1Sag/Adam11^tm1Sag	B6NCrj.Cg-Adam11^tm1Sag	MGI:3628649

Genotype
MGI:3628649

hm1

• Allelic Composition: Adam11^tm1Sag/Adam11^tm1Sag
• Genetic Background: B6NCrj.Cg-Adam11^tm1Sag

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:107127 )

• take significantly longer to locate the hidden platform in the Morris Water Maze task than controls, however the ability to find the hidden platform improves over test sessions

• in a probe trial in which the platform is removed following training, mutants spend significantly less time searching for the platform in the target quadrant, however exhibit normal performance in the visible platform task

impaired coordination ( J:107127 )

• fall off more quickly from a rotating rod than controls at 5, 10, and 15 rpm and the retention time does not improve in mutants across trails of training, however exhibit normal grip strength, spontaneous motor activity, and walking patterns