Phenotypes associated with this allele

• Allele Symbol: Rbp4^tm1.1Mma
• Allele Name: targeted mutation 1.1, Manuel Mark
• Allele ID: MGI:3625605
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbp4^tm1.1Mma/Rbp4^tm1.1Mma	involves: 129 * C57BL/6J	MGI:3629679
ht2	Rbp4^tm1.1Mma/Rbp4^+	involves: 129 * C57BL/6J	MGI:3629703

Genotype
MGI:3629679

hm1

• Allelic Composition: Rbp4^tm1.1Mma/Rbp4^tm1.1Mma
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal vitamin level ( J:108574 )

abnormal retinol level ( J:108574 )

• serum retinol levels were decreased by 98% in 15 week old mutant mice compared to wild-type littermates

reproductive system

abnormal testis morphology ( J:108574 )

♂ • prolonged vitamin A deficiency results in progressive testis degeneration

♂ • immature spermatids are released during spermatogenesis

♂ • testes show chronic loss of immature germ cells

abnormal gametogenesis ( J:108574 )

abnormal spermatogenesis ( J:108574 )

♂ • immature germ cells, as well as spermatozoa, are shed into the epidydimides

abnormal spermatid morphology ( J:108574 )

♂ • mild vitamin A deficiency results in desquamation of round spermatids

abnormal spermiation ( J:108574 )

♂ • mild vitamin A deficiency results in partial spermiation failure

♂ • IX and X spermatids are retained in seminiferous tubules longer than normal

♂ • some immature round spermatids detach from seminiferous epithelium and are released into tubule lumen

abnormal male reproductive system physiology ( J:108574 )

♂ • at 6 weeks of age, testicular levels of serum retinol and retinyl palmitate are 50% lower in mutant mice than in wild-type littermates

endocrine/exocrine glands

abnormal testis morphology ( J:108574 )

♂ • prolonged vitamin A deficiency results in progressive testis degeneration

♂ • immature spermatids are released during spermatogenesis

♂ • testes show chronic loss of immature germ cells

cellular

abnormal spermatid morphology ( J:108574 )

♂ • mild vitamin A deficiency results in desquamation of round spermatids

Genotype
MGI:3629703

ht2

• Allelic Composition: Rbp4^tm1.1Mma/Rbp4⁺
• Genetic Background: involves: 129 * C57BL/6J

homeostasis/metabolism

abnormal retinol level ( J:108574 )

• serum retinol levels are decreased by 40% in heterozygous compared to levels in wild-type mice