Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(HBB-GH1)420King transgene insertion 420, Donna King MGI:3625833 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• radiographic analysis of the caudal vertebrae of transgenic mice reveals greater bone density than in sex-matched control littermates from age 3 weeks, the difference increasing over time to 25-30% by 9 months
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• hemizygous females are unreliable breeders and mothers
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• vertebrae of transgenic mice appear "blocky" in comparison to control vertebrae
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• radiographic analysis of the caudal vertebrae of transgenic mice reveals greater bone density than in sex-matched control littermates from age 3 weeks, the difference increasing over time to 25-30% by 9 months
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• cortical bone thickness of the tibiae of transgenic mice is 20-45% greater than that of sex-matched control littermates
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• transgenic mice exhibit delayed mineralization at secondary ossification centers (epiphyses), which at 17 days of age are obvious in bones of controls but poorly formed in transgenic bone, and at 28 days are almost completely fused in control, but not transgenic, bone
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| N |
• radioimmunoassay for plasma levels of human growth hormone detected, on average, 536 ng/ml in 23 day old transgenic mice, which dropped to 228 ng/ml at 33 days and stabilized at ~195 ng/ml by 13 weeks, versus literature control values of 150-160 ng/ml of endogenous growth hormone
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• coats of hemizygous mice contain fewer guard hairs than wild-type controls'
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• skin of hemizygous mice exhibits unusual toughness or stiffness
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Ca4, Ca5 and Ca6 caudal vertebrae from male transgenic mice can tolerate a 25% greater maximum load (N) in compression at 12 weeks and a 31% greater maximum load at 6 months of age than can vertebrae from age- and sex-matched controls
• the energy to failure (Nmm) under compression of Ca4, Ca5 and Ca6 caudal vertebrae from male transgenic mice is 30% greater at 12 weeks and 55% greater at 6 months of age than that of vertebrae from age- and sex-matched controls
• the axial stiffness (N/mm) under compression of Ca4, Ca5 and Ca6 caudal vertebrae from male transgenic mice is 17% greater at 12 weeks and 36% greater at 6 months of age than that of vertebrae from age- and sex-matched wild-type controls
• Ca4, Ca5 and Ca6 caudal vertebrae from female transgenic mice can tolerate a 32% greater maximum load (N) in compression at 6 months of age than can vertebrae from age- and sex-matched controls; at 12 weeks, the difference was not significant
• the energy to failure (Nmm) under compression of Ca4, Ca5 and Ca6 caudal vertebrae from female transgenic mice is 26% greater at 6 months of age than that of vertebrae from age- and sex-matched controls; at 12 weeks, the difference was not significant
• the axial stiffness (N/mm) under compression of Ca4, Ca5 and Ca6 caudal vertebrae from female transgenic mice is 39% greater at 6 months of age than that of vertebrae from age- and sex-matched wild-type controls; at 12 weeks, the difference was not significant
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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