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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(HBB-GH1)420King
transgene insertion 420, Donna King
MGI:3625833
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(HBB-GH1)420King/Tg(HBB-GH1)420King involves: C57BL/6J * SJL MGI:3625837
tg2
Tg(HBB-GH1)420King/0 involves: C57BL/6J * SJL MGI:3626210
tg3
Tg(HBB-GH1)420King/? involves: C57BL/6J * SJL MGI:3626220


Genotype
MGI:3625837
tg1
Allelic
Composition
Tg(HBB-GH1)420King/Tg(HBB-GH1)420King
Genetic
Background
involves: C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HBB-GH1)420King mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• mice homozygous for this transgene are sterile




Genotype
MGI:3626210
tg2
Allelic
Composition
Tg(HBB-GH1)420King/0
Genetic
Background
involves: C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HBB-GH1)420King mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• radiographic analysis of the caudal vertebrae of transgenic mice reveals greater bone density than in sex-matched control littermates from age 3 weeks, the difference increasing over time to 25-30% by 9 months

reproductive system
• hemizygous females are unreliable breeders and mothers

skeleton
• vertebrae of transgenic mice appear "blocky" in comparison to control vertebrae
• radiographic analysis of the caudal vertebrae of transgenic mice reveals greater bone density than in sex-matched control littermates from age 3 weeks, the difference increasing over time to 25-30% by 9 months
• cortical bone thickness of the tibiae of transgenic mice is 20-45% greater than that of sex-matched control littermates
• transgenic mice exhibit delayed mineralization at secondary ossification centers (epiphyses), which at 17 days of age are obvious in bones of controls but poorly formed in transgenic bone, and at 28 days are almost completely fused in control, but not transgenic, bone

homeostasis/metabolism
N
• radioimmunoassay for plasma levels of human growth hormone detected, on average, 536 ng/ml in 23 day old transgenic mice, which dropped to 228 ng/ml at 33 days and stabilized at ~195 ng/ml by 13 weeks, versus literature control values of 150-160 ng/ml of endogenous growth hormone

integument
• coats of hemizygous mice contain fewer guard hairs than wild-type controls'
• skin of hemizygous mice exhibits unusual toughness or stiffness




Genotype
MGI:3626220
tg3
Allelic
Composition
Tg(HBB-GH1)420King/?
Genetic
Background
involves: C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HBB-GH1)420King mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• Ca4, Ca5 and Ca6 caudal vertebrae from male transgenic mice can tolerate a 25% greater maximum load (N) in compression at 12 weeks and a 31% greater maximum load at 6 months of age than can vertebrae from age- and sex-matched controls
• the energy to failure (Nmm) under compression of Ca4, Ca5 and Ca6 caudal vertebrae from male transgenic mice is 30% greater at 12 weeks and 55% greater at 6 months of age than that of vertebrae from age- and sex-matched controls
• the axial stiffness (N/mm) under compression of Ca4, Ca5 and Ca6 caudal vertebrae from male transgenic mice is 17% greater at 12 weeks and 36% greater at 6 months of age than that of vertebrae from age- and sex-matched wild-type controls
• Ca4, Ca5 and Ca6 caudal vertebrae from female transgenic mice can tolerate a 32% greater maximum load (N) in compression at 6 months of age than can vertebrae from age- and sex-matched controls; at 12 weeks, the difference was not significant
• the energy to failure (Nmm) under compression of Ca4, Ca5 and Ca6 caudal vertebrae from female transgenic mice is 26% greater at 6 months of age than that of vertebrae from age- and sex-matched controls; at 12 weeks, the difference was not significant
• the axial stiffness (N/mm) under compression of Ca4, Ca5 and Ca6 caudal vertebrae from female transgenic mice is 39% greater at 6 months of age than that of vertebrae from age- and sex-matched wild-type controls; at 12 weeks, the difference was not significant





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory