Phenotypes associated with this allele

• Allele Symbol: Xrcc6^tm1Gcl
• Allele Name: targeted mutation 1, Gloria C Li
• Allele ID: MGI:3625858
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xrcc6^tm1Gcl/Xrcc6^tm1Gcl	involves: 129S1/Sv * C57BL/6	MGI:3630384

Genotype
MGI:3630384

hm1

• Allelic Composition: Xrcc6^tm1Gcl/Xrcc6^tm1Gcl
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

proportional dwarf ( J:108657 )

• newborns are 40-60% smaller than wild-type and heterozygous littermates and during 5-month observation grew but maintained a body weight of 40-60% that of controls; like Xrcc5-null mice, Xrcc6-null mice are proportional dwarfs

cellular

abnormal cell physiology ( J:108657 )

• cells from null mice show a reduced ability to rejoin DNA double-strand breaks than wild-type

increased cellular sensitivity to ionizing radiation ( J:108657 )

• after exposure to ionizing radiation, bone marrow cells display less colony formation compared to wild-type

immune system

abnormal B cell differentiation ( J:108657 )

• B cells undergo D-J_H rearrangement at levels 10-50-fold lower than wild-type and 2-3-fold lower than Xrcc5^tm1Dbr homozygotes

absent mature B cells ( J:108657 )

• mice lack mature B cells

abnormal immune system organ morphology ( J:108657 )

• lymphoid tissues and organs appear smaller and disorganized compared to wild-type

small thymus ( J:108657 )

• thymus is disproportionately smaller

• thymus contains 50-100-fold fewer lymphocytes than wild-type

thymus hypoplasia ( J:108657 )

• thymus has over 50-fold less cells than wild-type

small spleen ( J:108657 )

• spleens are disproportionately smaller by 5-10-fold compared to wild-type

spleen hypoplasia ( J:108657 )

• spleen contains ~8-fold less cells than wild-type

decreased spleen white pulp amount ( J:108657 )

• spleen white pulp is reduced compared to wild-type

• there are no CD19-positive B cells in spleen white pulp in mutants

small lymph nodes ( J:108657 )

hematopoietic system

small thymus ( J:108657 )

• thymus is disproportionately smaller

• thymus contains 50-100-fold fewer lymphocytes than wild-type

thymus hypoplasia ( J:108657 )

• thymus has over 50-fold less cells than wild-type

abnormal B cell differentiation ( J:108657 )

• B cells undergo D-J_H rearrangement at levels 10-50-fold lower than wild-type and 2-3-fold lower than Xrcc5^tm1Dbr homozygotes

abnormal bone marrow cell morphology/development ( J:108657 )

• bone marrow reduced lymphoid cellularity compared to wild-type

absent mature B cells ( J:108657 )

• mice lack mature B cells

small spleen ( J:108657 )

• spleens are disproportionately smaller by 5-10-fold compared to wild-type

spleen hypoplasia ( J:108657 )

• spleen contains ~8-fold less cells than wild-type

decreased spleen white pulp amount ( J:108657 )

• spleen white pulp is reduced compared to wild-type

• there are no CD19-positive B cells in spleen white pulp in mutants

reproductive system

decreased litter size ( J:108657 )

• mice are fertile, but show reduced litter size (2-4 pups vs wild-type litters of ~8 pups)

endocrine/exocrine glands

small thymus ( J:108657 )

• thymus is disproportionately smaller

• thymus contains 50-100-fold fewer lymphocytes than wild-type

thymus hypoplasia ( J:108657 )

• thymus has over 50-fold less cells than wild-type