About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rasgrp3tm1Jstn
targeted mutation 1, James C Stone
MGI:3625862
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rasgrp3tm1Jstn/Rasgrp3tm1Jstn involves: 129P3/J * C57BL/6J MGI:3629772
cx2
 		Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Rasgrp3tm1Jstn/Rasgrp3tm1Jstn 		involves: 129P3/J * C57BL/6J MGI:3629773


Genotype
MGI:3629772
hm1
Allelic
Composition		 Rasgrp3tm1Jstn/Rasgrp3tm1Jstn
Genetic
Background		 involves: 129P3/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp3tm1Jstn mutation (1 available); any Rasgrp3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:108677 )
• during in vitro assays where B cells from young mice are co-stimulated with Il4 and anti-IgM, proliferation is defective compared to wild-type
• stimulation anti-IgM or co-stimulation with anti-IgM and anti-CD40 produces less proliferation than that seen in wild-type or Rasgrp1-deficient cultures
abnormal humoral immune response ( J:108677 )
• in both T-cell dependent and independent responses, mice produced weaker responses than wild-type
decreased IgG level ( J:108677 )
• mice exhibit lower titers of IgG1 and IgG2a in their sera compared to wild-type

hematopoietic system
decreased B cell number ( J:108677 )
• during in vitro assays where B cells from young mice are co-stimulated with Il4 and anti-IgM, proliferation is defective compared to wild-type
• stimulation anti-IgM or co-stimulation with anti-IgM and anti-CD40 produces less proliferation than that seen in wild-type or Rasgrp1-deficient cultures
decreased IgG level ( J:108677 )
• mice exhibit lower titers of IgG1 and IgG2a in their sera compared to wild-type




Genotype
MGI:3629773
cx2
Allelic
Composition		 Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Rasgrp3tm1Jstn/Rasgrp3tm1Jstn
Genetic
Background		 involves: 129P3/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1tm1Jstn mutation (1 available); any Rasgrp1 mutation (57 available)
Rasgrp3tm1Jstn mutation (1 available); any Rasgrp3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:108677 )
• during in vitro assays where B cells from young mice are co-stimulated with Il4 and anti-IgM, proliferation is lower than in wild-type or either single mutant
• B cells show weak proliferation when co-stimulated by anti-IgM and anti-CD40 compared to wild-type or either single mutant while response to anti-IgM, proliferative response to is weaker than wild-type or Rasgrp1-deficient mice
decreased plasma cell number ( J:108677 )
• mice have a lower proportion of CD138+ cells at 6 weeks compared to Rasgrp1-deficient mice
abnormal humoral immune response ( J:108677 )
• in T-cell independent responses, mice showed the greatest defect in T cell-dependent type I induction of IgG1 and IgG2a
• mice also show defective response in T cell-dependent response assays compared to wild-type

hematopoietic system
decreased B cell number ( J:108677 )
• during in vitro assays where B cells from young mice are co-stimulated with Il4 and anti-IgM, proliferation is lower than in wild-type or either single mutant
• B cells show weak proliferation when co-stimulated by anti-IgM and anti-CD40 compared to wild-type or either single mutant while response to anti-IgM, proliferative response to is weaker than wild-type or Rasgrp1-deficient mice
decreased plasma cell number ( J:108677 )
• mice have a lower proportion of CD138+ cells at 6 weeks compared to Rasgrp1-deficient mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory